Evidence map›Paper›PMID 33067442›Full record

ArticleNature communications2020

Non-invasive decision support for NSCLC treatment using PET/CT radiomics.

Wei Mu, Lei Jiang, JianYuan Zhang, Yu Shi, Jhanelle E Gray, Ilke Tunali, Chao Gao, Yingying Sun, Jie Tian, Xinming Zhao and 3 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 6 pooled it
23.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 6 syntheses or guidelines pooled it, 291 citations in OpenAlex.

  1. Pooled it
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  4. Predictive value ofFrontiers in oncology · 2024
    Pooled it
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  6. CanBMJ open · 2021
    Pooled it
  7. Trial
  8. Diagnostic accuracy of image-based deep learning for glaucomatous optic neuropathy detection: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wei MuDepartment of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID 0000-0001-7970-8666
Lei JiangDepartment of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
JianYuan ZhangDepartment of Nuclear Medicine, the Fourth Hospital of Hebei Medical University, Hebei, China.ORCID 0000-0002-6400-2051
Yu ShiDepartment of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Jhanelle E GrayDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Ilke TunaliDepartment of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Chao GaoNHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China.
Yingying SunNHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China.
Jie TianBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China.ORCID 0000-0003-0498-0432
Xinming ZhaoDepartment of Nuclear Medicine, the Fourth Hospital of Hebei Medical University, Hebei, China. xinm_zhao@163.com.ORCID 0000-0002-7060-2643
Xilin SunNHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China. sunxl@ems.hrbmu.edu.cn.ORCID 0000-0001-7464-5117
Robert J GilliesDepartment of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Robert.Gillies@Moffitt.org.ORCID 0000-0002-8888-7747
Matthew B SchabathDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. matthew.schabath@moffitt.org.ORCID 0000-0003-3241-3216
Moffitt Cancer Center · USHarbin Medical University · CNHebei Medical University · CNChinese Academy of Sciences · CNTongji University · CN

Funding

Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
(PQC4) Habitats in Prostate CancerR01CA190105 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BALAGURUNATHAN, YOGANAND, GILLIES, ROBERT J. · 2014 to 2017
$2.8M
NCI NIH HHS R01 CA190105NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA200464
6 · The paper itself

Abstract

Two major treatment strategies employed in non-small cell lung cancer, NSCLC, are tyrosine kinase inhibitors, TKIs, and immune checkpoint inhibitors, ICIs. The choice of strategy is based on heterogeneous biomarkers that can dynamically change during therapy. Thus, there is a compelling need to identify comprehensive biomarkers that can be used longitudinally to help guide therapy choice. Herein, we report a

Indexed as

Deep LearningAgedCarcinoma, Non-Small-Cell LungErbB ReceptorsFemaleHumansLung NeoplasmsMaleMiddle AgedMutationPositron Emission Tomography Computed TomographyProgression-Free SurvivalProtein Kinase InhibitorsEGFR protein, humanErbB ReceptorsProtein Kinase Inhibitors

Identifiers

PMID33067442
PMCPMC7567795
OpenAlexW3093156106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.