Evidence map›Paper›PMID 33067441›Full record

ArticleNature communications2020

Photon-directed multiplexed enzymatic DNA synthesis for molecular digital data storage.

Howon Lee, Daniel J Wiegand, Kettner Griswold, Sukanya Punthambaker, Honggu Chun, Richie E Kohman, George M Church

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
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  8. Review
  9. Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Cost-Effective DNA Storage System with DNA Movable Type.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Howon LeeDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Daniel J WiegandDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0001-8299-5125
Kettner GriswoldDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Sukanya PunthambakerDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0001-6878-9990
Honggu ChunDepartment of Biomedical Engineering, Korea University, 466 Hana Science Hall, 145 Anamro, Seongbukgu, 02841, Seoul, South Korea.
Richie E KohmanDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA. richie.kohman@wyss.harvard.edu.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA. gchurch@genetics.med.harvard.edu.ORCID 0000-0003-3535-2076
Harvard University · USDraper Laboratory · USKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New storage technologies are needed to keep up with the global demands of data generation. DNA is an ideal storage medium due to its stability, information density and ease-of-readout with advanced sequencing techniques. However, progress in writing DNA is stifled by the continued reliance on chemical synthesis methods. The enzymatic synthesis of DNA is a promising alternative, but thus far has not been well demonstrated in a parallelized manner. Here, we report a multiplexed enzymatic DNA synthesis method using maskless photolithography. Rapid uncaging of Co

Indexed as

DNADNA NucleotidylexotransferaseInformation Storage and RetrievalOligonucleotide Array Sequence AnalysisOligonucleotidesUltraviolet RaysDNADNA NucleotidylexotransferaseOligonucleotides

Identifiers

PMID33067441
PMCPMC7567835
OpenAlexW3092961501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.