Observational studyJournal of immunology (Baltimore, Md. : 1950)2020
Innate Immune Responses and Gut Microbiomes Distinguish HIV-Exposed from HIV-Unexposed Children in a Population-Specific Manner.
Observational study in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Maternal and early-life longitudinal cytokine profiles in a South African birth cohort: the impact of HIV.bioRxiv : the preprint server for biology · 2025Article
- Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review.African journal of primary health care & family medicine · 2025Article
- Epigenetic modifications and immune responses in HIV-infected infants: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Gut microbiota and other factors associated with increased T cell regulation in HIV-exposed uninfected infants.Frontiers in immunology · 2025Article
- Cord blood innate-like T cell responses in neonates born to healthy women and women living with HIV.Frontiers in immunology · 2025Article
- Maternal HIV infection and the milk microbiome.Microbiome · 2024Article
- Review
- Longitudinal gut microbiota composition of South African and Nigerian infants in relation to tetanus vaccine responses.Microbiology spectrum · 2024Article
- Clinical and immunological outcomes of HIV-exposed uninfected and HIV-unexposed uninfected children in the first 24 months of life in Western Kenya.BMC infectious diseases · 2024Article
- Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life.Frontiers in immunology · 2024Article
- Longitudinal gut microbiota composition of South African and Nigerian infants in relation to tetanus vaccine responses.Research square · 2023Article
- The gut microbiome and early-life growth in a population with high prevalence of stunting.Nature communications · 2023Article
- Review
- Article
- Editorial: HIV and ART in children.Frontiers in pediatrics · 2022Article
- Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.Cytokine · 2021Article
- Searching for a technology-driven acute rheumatic fever test: the START study protocol.BMJ open · 2021Article
- Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System.mBio · 2021Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 5 countries.
Funding
Abstract
In both high- and low-income countries, HIV-negative children born to HIV-positive mothers (HIV exposed, uninfected [HEU]) are more susceptible to severe infection than HIV-unexposed, uninfected (HUU) children, with altered innate immunity hypothesized to be a cause. Both the gut microbiome and systemic innate immunity differ across biogeographically distinct settings, and the two are known to influence each other. And although the gut microbiome is influenced by HIV infection and may contribute to altered immunity, the biogeography of immune-microbiome correlations among HEU children have not been investigated. To address this, we compared the innate response and the stool microbiome of 2-y-old HEU and HUU children from Belgium, Canada, and South Africa to test the hypothesis that region-specific immune alterations directly correlate to differences in their stool microbiomes. We did not detect a universal immune or microbiome signature underlying differences between HEU versus HUU that was applicable to all children. But as hypothesized, population-specific differences in stool microbiomes were readily detected and included reduced abundances of short-chain fatty acid-producing bacteria in Canadian HEU children. Furthermore, we did not identify innate immune-microbiome associations that distinguished HEU from HUU children in any population. These findings suggest that maternal HIV infection is independently associated with differences in both innate immunity and the stool microbiome in a biogeographical population-specific way.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.