Evidence map›Paper›PMID 33067362›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

A Central Amygdala-Globus Pallidus Circuit Conveys Unconditioned Stimulus-Related Information and Controls Fear Learning.

Jacqueline Giovanniello, Kai Yu, Alessandro Furlan, Gregory Thomas Nachtrab, Radhashree Sharma, Xiaoke Chen, Bo Li

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Review
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  7. Review
  8. GPe Projections to the Retrorubral Field Give Rise to Diverging GABAergic and DAergic Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025
    Review
  10. Article
  11. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jacqueline GiovannielloSchool of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.ORCID 0000-0002-4558-7728
Kai YuCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.ORCID 0000-0003-1481-1288
Alessandro FurlanCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Gregory Thomas NachtrabDepartment of Biology, Stanford University, California 94305.
Radhashree SharmaCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Xiaoke ChenDepartment of Biology, Stanford University, California 94305.
Bo LiSchool of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 bli@cshl.edu.ORCID 0000-0002-0154-3088
Cold Spring Harbor Laboratory · USStanford University · US

Funding

Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
The basal ganglia–habenula circuitry in reward processingR01MH108924 · NIMH · COLD SPRING HARBOR LABORATORY · PI Jessica Tollkuhn · 2015 to 2026
$6.8M
The central amygdala circuits in motivated behaviorsR01MH101214 · NIMH · COLD SPRING HARBOR LABORATORY · PI VAN AELST, LINDA · 2014 to 2024
$6.3M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.R01NS104944 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, BO, MAO, TIANYI · 2018 to 2022
$5.0M
CSHL Watson School of Biological SciencesT32GM065094 · NIGMS · COLD SPRING HARBOR LABORATORY · PI GANN, ALEXANDER · 2002 to 2021
$4.8M
Thalamic Circuits Underlying Opioid SeekingR01DA045664 · NIDA · STANFORD UNIVERSITY · PI CHEN, XIAOKE · 2018 to 2022
$2.3M
NIDA NIH HHS R01 DA045664NIDA NIH HHS T32 DA024635NIDA NIH HHS T32 DA035165NIGMS NIH HHS T32 GM065094NIMH NIH HHS R01 MH101214NIMH NIH HHS R01 MH108924NINDS NIH HHS R01 NS104944
6 · The paper itself

Abstract

The central amygdala (CeA) is critically involved in a range of adaptive behaviors, including defensive behaviors. Neurons in the CeA send long-range projections to a number of extra-amygdala targets, but the functions of these projections remain elusive. Here, we report that a previously neglected CeA-to-globus pallidus external segment (GPe) circuit plays an essential role in classical fear conditioning. By anatomic tracing,

Indexed as

Acoustic StimulationAnimalsCentral Amygdaloid NucleusConditioning, ClassicalFearFemaleGlobus PallidusLearningMaleMiceMice, Inbred C57BLNerve NetOptogeneticsSomatostatinTetanus ToxinSomatostatinTetanus Toxincentral amygdalafear conditioningglobus palliduslearningsomatostatinunconditioned stimulus

Identifiers

PMID33067362
PMCPMC7673004
OpenAlexW3092873902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.