ArticleBMJ open2020
Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005-2018: a Danish nationwide register-based cohort study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reported outcome measures in necrotising soft tissue infections: a systematic review.Diving and hyperbaric medicine · 2024Pooled it
- Equipoise: an important ethical consideration when contemplating participation in a randomised controlled trial of hyperbaric oxygen treatment in necrotising soft tissue infections.Diving and hyperbaric medicine · 2024Trial
- Rare Case of Necrotizing Fasciitis With Polyarteritis Nodosa in a Multi-Comorbid Patient.Clinical case reports · 2026Article
- Temporal Changes in Diagnostic Composition and Treatment Activity Among Mechanically Ventilated ICU Patients Receiving Hyperbaric Oxygen Therapy: An 11-Year Single-Centre Retrospective Study.Journal of clinical medicine · 2026Article
- Article
- Multifocal necrotizing fasciitis: what makes it different? A German trauma center experience.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Incidence and risk factors for postoperative myocardial infarction following hip and knee arthroplasty.Bone & joint open · 2026Article
- Clinical Features of Clostridial Necrotizing Soft-tissue Infections: Analysis of a Prospective Scandinavian Cohort Study.Open forum infectious diseases · 2026Article
- Aggressive end-of-life care among over half a million patients with cancer in Shandong, China, 2017-2022.Journal of global health · 2026Article
- Hospital ward transitions and outcomes in critical care survivors: A multi-hospital cohort study.Journal of the Intensive Care Society · 2026Article
- Factors associated with in-hospital mortality in necrotising soft tissue infections. a multicentre retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Outcomes and Predictors of Fungal Necrotizing Soft Tissue Infections.Surgical infections · 2026Article
- A Case of Cervical Necrotising Fasciitis Precipitated by Hypopharyngeal Squamous Cell Carcinoma.Cureus · 2026Article
- A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data.BMC medicine · 2026Article
- Association between the direct bilirubin to lymphocyte ratio and mortality in patients with necrotizing fasciitis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Necrotizing myofasciitis: management in the emergency department using PoCUS. A case report.Journal of ultrasound · 2025Article
- Characteristics, treatments, and outcomes of patients with necrotizing soft tissue infections: a Dutch multicenter cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Antibiotic therapy in necrotizing soft tissue infections: a narrative review of the greater Paris SURFAST consortium.Critical care (London, England) · 2025Review
- Exclusion of Necrotizing Soft-tissue Infection in a Patient with Malpositioned Intraosseous Access: A Case Report.Journal of orthopaedic case reports · 2025Article
- A development of machine learning models to preoperatively predict insufficient clinical improvement after total knee arthroplasty.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the incidence, comorbidities, treatment modalities and mortality in patients with necrotising soft-tissue infections (NSTIs) in Denmark.
designNationwide population-based registry study.
settingDenmark.
participantsDanish residents with NSTI between 1 January 2005 and 31 August 2018.
main outcome measureIncidence of disease per 100 000 person/year and all-cause mortality at day 90 obtained from Danish National Patient Registry and the Danish Civil Registration System.
results1527 patients with NSTI were identified, yielding an incidence of 1.99 per 100 000 person/year. All-cause 30-day, 90-day and 1-year mortality were 19.4% (95% CI 17.4% to 21.5%), 25.2% (95% CI 23.1% to 27.5%) and 30.4% (95% CI 28.0% to 32.8%), respectively. Amputation occurred in 7% of the individuals. Diabetes was the most predominant comorbidity affecting 43% of the cohort, while 26% had no comorbidities. Higher age, female sex and increasing comorbidity index were found to be independent risk factors of mortality. Admission to high-volume hospitals was associated with improved survival (OR 0.59, 95% CI 0.45 to 0.77). Thirty-six per cent received hyperbaric oxygen therapy (HBOT) as an adjunctive therapy. No change in overall mortality was found over the studied time period.
conclusionThe present study found that in Denmark, the incidence of NSTI increased; mortality rates remained high and largely unaltered. Diabetes was the most common comorbidity, while higher age, female sex and increasing comorbidity index were associated to increased mortality. Survival was improved in those admitted to hospitals with more expertise in treating NSTI. In high-volume hospital, HBOT was associated with decreased odds for mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.