ArticleScience advances2020
Context-dependent plasticity of adult-born neurons regulated by cortical feedback.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Distinct Ultrastructural Properties and Plasticity of Synapses Formed by Adult-Born and Early-Born Interneurons in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Advances in intravital imaging of adult neurogenesis in mice.Stem cell reports · 2025Review
- Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.The Journal of comparative neurology · 2025Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Role of Odor Novelty on Olfactory Issues in Autism Spectrum Disorder.Genes, brain, and behavior · 2024Review
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity.Neurobiology of stress · 2024Article
- Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex.Nature communications · 2024Article
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells.PLoS biology · 2024Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.bioRxiv : the preprint server for biology · 2023Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.Advances in neural information processing systems · 2023Article
- Bridging event-related potentials with behavioral studies in motor learning.Frontiers in integrative neuroscience · 2023Review
- Long-range GABAergic projections contribute to cortical feedback control of sensory processing.Nature communications · 2022Article
- Structural spine plasticity: Learning and forgetting of odor-specific subnetworks in the olfactory bulb.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
In a complex and dynamic environment, the brain flexibly adjusts its circuits to preferentially process behaviorally relevant information. Here, we investigated how the olfactory bulb copes with this demand by examining the plasticity of adult-born granule cells (abGCs). We found that learning of olfactory discrimination elevates odor responses of young abGCs and increases their apical dendritic spines. This plasticity did not occur in abGCs during passive odor experience nor in resident granule cells (rGCs) during learning. Furthermore, we found that feedback projections from the piriform cortex show elevated activity during learning, and activating piriform feedback elicited stronger excitatory postsynaptic currents in abGCs than rGCs. Inactivation of piriform feedback blocked abGC plasticity during learning, and activation of piriform feedback during passive experience induced learning-like plasticity of abGCs. Our work describes a neural circuit mechanism that uses adult neurogenesis to update a sensory circuit to flexibly adapt to new behavioral demands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.