Evidence map›Paper›PMID 33067233›Full record

ArticleScience advances2020

Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices.

Byoung Soo Kim, Min Ku Kim, Younghak Cho, Eman E Hamed, Martha U Gillette, Hyeongyun Cha, Nenad Miljkovic, Vinay K Aakalu, Kai Kang, Kyung-No Son and 11 more

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Classification and Evaluation of Octopus-Inspired Suction Cups for Soft Continuum Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  6. Article
  7. Artificial neuromorphic cognitive skins based on distributed biaxially stretchable elastomeric synaptic transistors.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Suction Cups-Inspired Adhesive Patch with Tailorable Patterns for Versatile Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Byoung Soo KimDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-4023-7323
Min Ku KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-2576-5793
Younghak ChoDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Eman E HamedNeuroscience Program, Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-2608-210X
Martha U GilletteNeuroscience Program, Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0003-3645-2626
Hyeongyun ChaDepartment of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0001-7157-7315
Nenad MiljkovicDepartment of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-0866-3680
Vinay K AakaluIllinois Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA.
Kai KangIllinois Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA.
Kyung-No SonIllinois Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-6095-2175
Kyle M SchachtschneiderDepartment of Radiology, University of Chicago, Chicago, IL 60612, USA.
Lawrence B SchookDepartment of Radiology, University of Chicago, Chicago, IL 60612, USA.
Chenfei HuDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-9578-966X
Gabriel PopescuDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-8296-8095
Yeonsoo ParkWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
William C BallanceDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Seunggun YuInsulation Materials Research Center, Korea Electrotechnology Research Institute (KERI), Changwon 51543, Republic of Korea.
Sung Gap ImDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0002-2802-6398
Jonghwi LeeDepartment of Chemical Engineering and Materials Science, Chung-Ang University, Seoul 06974, Republic of Korea. hjkong06@illinois.edu lee2270@purdue.edu jong@cau.ac.kr.ORCID 0000-0003-2336-8695
Chi Hwan LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. hjkong06@illinois.edu lee2270@purdue.edu jong@cau.ac.kr.ORCID 0000-0002-4868-7054
Hyunjoon KongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. hjkong06@illinois.edu lee2270@purdue.edu jong@cau.ac.kr.ORCID 0000-0003-4680-2968

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Novel Treatments for Ocular Surface DiseasesR01EY029409 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AAKALU, VINAY · 2019 to 2023
$1.9M
Nanocells for vascular normalization therapiesR01HL109192 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2011 to 2015
$1.9M
Study of Accessory Lacrimal Gland and Precursor Cell BiologyK08EY024339 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AAKALU, VINAY · 2014 to 2018
$1.2M
Development and Validation of Mechanically Compliant Wearable Monitoring Systems for Swallowing Function and DisordersR21EB026099 · NIBIB · PURDUE UNIVERSITY · PI LEE, CHI HWAN, MALANDRAKI, GEORGIA · 2019 to 2021
$563k
Novel Treatments for Modulation of Innate Immunity in Veteran Related Eye DiseasesI01BX004080 · VA · JESSE BROWN VA MEDICAL CENTER · PI AAKALU, VINAY · 2019 to 2023
–
BLRD VA I01 BX004080NEI NIH HHS K08 EY024339NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY029409NHLBI NIH HHS R01 HL109192NIBIB NIH HHS R21 EB026099
6 · The paper itself

Abstract

"Living" cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod's suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.

Identifiers

PMID33067233
PMCPMC7567602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.