Evidence map›Paper›PMID 33066919›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2020

A Prehospital Acute Stroke Trial has Only Modest Impact on Enrollment in Concurrent, Post-arrival-Recruiting Stroke Trials.

Phoebe Johnson-Black, Gregory Wong, Sidney Starkman, Nerses Sanossian, Latisha Sharma, May Kim-Tenser, David Liebeskind, Lucas Restrepo-Jimenez, Miguel Valdes-Sueiras, Samuel Stratton and 10 more

Abstract read
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In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Phoebe Johnson-BlackUniv of Los Angeles, 710 Westwood Plaza, Los Angeles 90095, CA, United States. Electronic address: phoebejohnson@mednet.ucla.edu.
Gregory WongUniversity of Washington, St. Louis, MO, United States.
Sidney StarkmanUniv of California, Los Angeles, Los Angeles, CA, United States.
Nerses SanossianUniv of Southern California, Los Angeles, CA, United States.
Latisha SharmaUniv of California, Los Angeles, Los Angeles, CA, United States.
May Kim-TenserUniv of California, Los Angeles, Los Angeles, CA, United States.
David LiebeskindUniv of California, Los Angeles, Los Angeles, CA, United States.
Lucas Restrepo-JimenezUniv of California, Los Angeles, Los Angeles, CA, United States.
Miguel Valdes-SueirasUniv of California, Los Angeles, Los Angeles, CA, United States.
Samuel StrattonUniv of California, Los Angeles, Los Angeles, CA, United States.
Marc EcksteinUniv of Southern California, Los Angeles, CA, United States.
Frank PrattUniv of California, Los Angeles, Los Angeles, CA, United States.
Robin ConwitNINDS, Bethesda, MD, United States.
Scott HamiltonStanford Univ, Palo Alto, CA, United States.
Judy GuzyUniv of California, Los Angeles, Los Angeles, CA, United States.
Ileana GrunbergUniv of California, Los Angeles, Los Angeles, CA, United States.
Kristina ShkirkovaUniv of California, Los Angeles, Los Angeles, CA, United States.
Claude HemphillUniv of California, San Francisco, San Francisco, CA, United States.
Jeffrey SaverUniv of California, Los Angeles, Los Angeles, CA, United States.
FAST-MAG Investigators and CoordinatorsUniversity of California, Department of Neurology, Los Angeles, United States.

Funding

Field Administration of Stroke Therapy-Magnesium Trial (FAST-MAG)U01NS044364 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAVER, JEFFREY L · 2003 to 2013
$46.4M
NINDS NIH HHS U01 NS044364
6 · The paper itself

Abstract

backgroundBecause "time is brain," acute stroke trials are migrating to the prehospital setting. The impact upon enrollment in post-arrival trials of earlier recruitment in a prehospital trial requires delineation.

methodsWe analyzed all patients recruited into acute and prevention stroke trials during an 8-year period when an academic medical center (AMC) was participating in a prehospital treatment trial - the NIH Field Administration of Stroke Treatment - Magnesium (FAST-MAG) study.

resultsDuring the study period, in addition to FAST-MAG, the AMC participated in 33 post-arrival stroke trials: 27 for acute cerebral ischemia, one for intracerebral hemorrhage, and 5 secondary prevention trials. Throughout the study period, the AMC was recruiting for at least 3 concurrent post-arrival acute trials. Among 199 patients enrolled in acute stroke trials, 98 (49%) were in FAST-MAG and 101 (51%) in concurrent, post-arrival acute trials. Among FAST-MAG patients, 67% were not eligible for any concurrent acute, post-arrival trial. Of 134 patients eligible for post-arrival acute trials, 101 (76%) were enrolled in post-arrival trials and 32 (24%) in FAST-MAG. Leading reasons FAST-MAG patients were ineligible for post-arrival acute trials were: NIHSS too low (23.4%), intracranial hemorrhage (17.9%), IV tPA used in standard management (9.0%), NIHSS too high (7.1%), and age too high (5.2%).

conclusionsA prehospital hyperacute stroke trial with wide entry criteria reduced only modestly, by one-fourth, enrollment into concurrently active, post-arrival stroke trials. Simultaneous performance of prehospital and post-arrival acute and secondary prevention stroke trials in research networks is feasible.

Indexed as

Clinical Trials, Phase III as TopicEmergency Medical ServicesMulticenter Studies as TopicPatient AdmissionPatient SelectionRandomized Controlled Trials as TopicAcademic Medical CentersAdultAgedAged, 80 and overDouble-Blind MethodEligibility DeterminationFemaleHumansMaleMiddle AgedAcute stroke trialsClinical trialsConcurrent trialsFAST-MAGPrehospital trialsTrial design

Identifiers

PMID33066919
PMCPMC7573197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.