ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2020
Standardized Fabrication Method of Human-Derived Emboli with Histologic and Mechanical Quantification for Stroke Research.
Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Clinical image analysis to build patient-specific models of acute ischemic stroke patients.Physical and engineering sciences in medicine · 2026Article
- Characterization of the In Situ Stress State of Blood Clots in Ischemic Stroke: The Effect of Initial Conditions and Arterial Interaction.International journal for numerical methods in biomedical engineering · 2025Article
- The modified placenta model for microsurgery training: Recommended methods for comprehensive microsurgery experience.Journal of hand and microsurgery · 2024Article
- Safety Window for Effective Lesion Crossing in Patients With Chronic Thromboembolic Pulmonary Hypertension.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Flow affects the structural and mechanical properties of the fibrin network in plasma clots.Journal of materials science. Materials in medicine · 2024Article
- In vitro models for the experimental evaluation of mechanical thrombectomy devices in acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Review
- Tensile and Compressive Mechanical Behaviour of Human Blood Clot Analogues.Annals of biomedical engineering · 2023Article
- An in vitro model for Extracellular DNA Traps (ETs)-rich Human Thrombus Analogs.Journal of neurointerventional surgery · 2023Article
- Construction and Validation of a Benchtop Model for Testing of Mechanical Thrombectomy Devices for Pulmonary Embolism.Cardiovascular and interventional radiology · 2023Article
- Quantification of clot spatial heterogeneity and its impact on thrombectomy.Journal of neurointerventional surgery · 2022Article
- A Thrombectomy Model Based on Ex Vivo Whole Human Brains.AJNR. American journal of neuroradiology · 2021Article
- A novel rabbit thromboembolic occlusion model.Journal of neurointerventional surgery · 2021Article
- Finite element analysis of blood clots based on the nonlinear visco-hyperelastic model.Biophysical journal · 2021Article
- Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models.Journal of neurointerventional surgery · 2021Review
- In Vitro Study of Blood Clot Identification and Composition Assessment by Different Magnetic Resonance Sequences.Cureus · 2021Article
- Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing.AJNR. American journal of neuroradiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAs access to patient emboli is limited, embolus analogs (EAs) have become critical to the research of large vessel occlusion (LVO) stroke and the development of thrombectomy technology. To date, techniques for fabricating standardized human blood-derived EAs are limited in the variety of compositions, and the mechanical properties relevant to thrombectomy are not quantified.
methodsEAs were made by mixing human banked red blood cells (RBCs), plasma, and platelet concentrate in 10 different volumetric percentage combinations to mimic the broad range of patient emboli causing LVO strokes. The samples underwent histologic analysis and tensile testing to mimic the pulling action of thrombectomy devices, and were compared to patient emboli.
resultsEAs had histologic compositions of 0-96% RBCs, 0.78%-92% fibrin, and 2.1%-22% platelets, which can be correlated with the ingredients using a regression model. At fracture, EAs elongated from 81% to 136%, and the ultimate tensile stress ranged from 16 to 949 kPa. These EAs' histologic compositions and tensile properties showed great similarity to those of emboli retrieved from LVO stroke patients, indicating the validity of such EA fabrication methods. EAs with lower RBC and higher fibrin contents are more extensible and can withstand higher tensile stress.
conclusionsEAs fabricated and tested using the proposed new methods provide a platform for stroke research and pre-clinical development of thrombectomy devices.
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