ReviewNutrients2020
Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06995586 (The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.), which is not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020.Eye (London, England) · 2024Pooled it
- The Hippo signalling pathway and its impact on eye diseases.Journal of cellular and molecular medicine · 2024Pooled it
- Compound electrolyte intraocular irrigating solution produces better effects on vision recovery of cataract patients after surgery than Ringer lactate solution.International ophthalmology · 2024Trial
- Plant-based diet quality and risk of age-related eye diseases: evidence from multi-cohorts with multi-omics insights.NPJ science of food · 2026Article
- Assessing the therapeutic effects of DPP4 Inhibitors on TGF-β2-induced Lens Opacity.Experimental eye research · 2026Article
- Vitamins and nutraceuticals in glaucoma research.European journal of ophthalmology · 2026Review
- The Relationship of the Red Cell Distribution Width-to-Albumin Ratio and Other Inflammatory Markers With Cataracts: An Analysis of the NHANES Population.Translational vision science & technology · 2026Article
- Highly Sensitive Zinc Oxide Nanorods for Non-Enzyme Electrochemical Detection of Ascorbic and Uric Acids.Biosensors · 2026Article
- Identification and validation of druggable targets for cataract using mendelian randomization: functional insights from multi-omics and an oxidative stress model.Frontiers in medicine · 2026Article
- Review
- Replacing the vitreous body with hydrogels: Rationale and strategies.Progress in retinal and eye research · 2025Review
- Antioxidant Molecules in the Human Vitreous Body During Prenatal Eye Development.Antioxidants (Basel, Switzerland) · 2025Review
- Endoplasmic reticulum stress involved in age-related nuclear cataract induced by sodium selenite.Scientific reports · 2025Article
- [Regulatory Role of the AKT1/AMPK Pathway in Oxidative Stress of Lens Epithelial Cells in Cataract Patients].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Exploring the association between composite dietary antioxidant index and ocular diseases: a cross-sectional study.BMC public health · 2025Article
- Association of dietary inflammatory index with ocular diseases: a population-based cross-sectional study.European journal of medical research · 2025Article
- Association between systemic immune inflammation index and cataract incidence from 2005 to 2008.Scientific reports · 2025Article
- Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review).Molecular medicine reports · 2025Review
- In Vivo Assessment of an Antioxidant Hydrogel Vitreous Substitute.Journal of biomedical materials research. Part A · 2025Article
- Protective Effect ofAdvanced biomedical research · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and diabetes are major risk factors, and with an increasing aging and diabetic population, the burden of cataracts will grow. Cataract surgery is an effective way to restore vision; however, alternatives to cataract surgery are required to reduce the looming cataract epidemic. Since it is well established that oxidative damage plays a major role in the etiology of cataracts, antioxidants have been promoted as therapies to delay and/or prevent cataracts. However, many antioxidant interventions including vitamin C have produced mixed results as anti-cataract therapies. Progress has been made towards our understanding of lens physiology and the mechanisms involved in the delivery and uptake of antioxidants to the lens which may guide future studies aimed at addressing some of the inconsistencies seen in previous animal and human studies. Of interest is the potential for vitamin C based supplements in delaying the onset of cataracts post vitrectomy which occurs in up to 80% of patients within two years. These targeted approaches are required to reduce the burden of cataract on hospitals and improve the quality of life of our aging and diabetic population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.