Evidence map›Paper›PMID 33066671›Full record

ArticleMolecules (Basel, Switzerland)2020

Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer.

Noeen Malik, Shreya Bendre, Ralf Schirrmacher, Paul Schaffer

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Nitropyridines in the Synthesis of Bioactive Molecules.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Noeen MalikLife Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada.
Shreya BendreMolecular Oncology, BCCRC, 675 W 10th Ave, Vancouver, BC V5Z 1L3, Canada.
Ralf SchirrmacherLife Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada.ORCID 0000-0002-7098-3036
Paul SchafferLife Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada.
TRIUMF · CA

Funding

Canadian Cancer Society Research Institute 705808
6 · The paper itself

Abstract

backgroundTemperature-sensitive radiopharmaceutical precursors require lower reaction temperatures (<100 °C) during nucleophilic radiofluorination in order to avoid compound thermolysis, often resulting in sub-optimal radiochemical yields (RCYs). To facilitate nucleophilic aromatic substitution (S

methodsTo a vessel containing dried K[

resultsNon-decay corrected radiochemical yields (ndc RCYs) for [

conclusionRCYs of [

Indexed as

Fluorine RadioisotopesIsotope LabelingLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lewis AcidsOrganometallic CompoundsRadiopharmaceuticalsTemperatureUreaFluorine-18Fluorine RadioisotopesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lewis AcidsLRRK2 protein, humanOrganometallic CompoundsRadiopharmaceuticalstitanocene dichlorideUreaLewis acidsLRRK2nucleophilic aromatic substitutionsradiofluorination

Identifiers

PMID33066671
PMCPMC7587332
OpenAlexW3093001518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.