Evidence map›Paper›PMID 33066509›Full record

ReviewMolecules (Basel, Switzerland)2020

Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals.

Seung Wan Son, Han Yeoung Lee, Sokviseth Moeng, Hyo Jeong Kuh, Soo Young Choi, Jong Kook Park

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Hypoxia A Typical Target in Human Lung Cancer Therapy.Current protein & peptide science · 2024
    Review
  5. Review
  6. Role of Diet in Stem and Cancer Stem Cells.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. International journal of molecular sciences · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Seung Wan SonDepartment of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea.
Han Yeoung LeeDepartment of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea.
Sokviseth MoengDepartment of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea.
Hyo Jeong KuhDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Soo Young ChoiDepartment of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea.
Jong Kook ParkDepartment of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea.ORCID 0000-0002-3946-5687
Hallym University · KRCatholic University of Korea · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education 2017R1D1A3B03035662Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education 2019R1A6A1A11036849National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) 2019R1A2C1089710National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) 2019R1A5A2027588
6 · The paper itself

Abstract

Cancer is a global health concern and one of the main causes of disease-related death. Even with considerable progress in investigations on cancer therapy, effective anti-cancer agents and regimens have thus far been insufficient. There has been compelling evidence that natural phytochemicals and their derivatives have potent anti-cancer activities. Plant-based anti-cancer agents, such as etoposide, irinotecan, paclitaxel, and vincristine, are currently being applied in medical treatments for patients with cancer. Further, the efficacy of plenty of phytochemicals has been evaluated to discover a promising candidate for cancer therapy. For developing more effective cancer therapy, it is required to apprehend the molecular mechanism deployed by natural compounds. MicroRNAs (miRNAs) have been realized to play a pivotal role in regulating cellular signaling pathways, affecting the efficacy of therapeutic agents in cancer. This review presents a feature of phytochemicals with anti-cancer activity, focusing mainly on the relationship between phytochemicals and miRNAs, with insights into the role of miRNAs as the mediators and the regulators of anti-cancer effects of phytochemicals.

Indexed as

AnimalsAnticarcinogenic AgentsAntineoplastic Agents, PhytogenicClinical Trials as TopicGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansMicroRNAsNeoplasmsPhytochemicalsAnticarcinogenic AgentsAntineoplastic Agents, PhytogenicMicroRNAsPhytochemicalscancermicroRNAnatural compoundnon-coding RNAphytochemical

Identifiers

PMID33066509
PMCPMC7587345
OpenAlexW3093171625

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.