Evidence map›Paper›PMID 33066378›Full record

ArticleMolecules (Basel, Switzerland)2020

New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition.

Audrey Isabel Chiasson, Samuel Robichaud, Fanta J Ndongou Moutombi, Mathieu P A Hébert, Maroua Mbarik, Marc E Surette, Mohamed Touaibia

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. Active Compounds inInternational journal of molecular sciences · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Audrey Isabel ChiassonDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Samuel RobichaudDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Fanta J Ndongou MoutombiDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Mathieu P A HébertDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Maroua MbarikDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Marc E SuretteDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.
Mohamed TouaibiaDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A3E9, Canada.ORCID 0000-0003-3744-8012
Université de Moncton · CA

Funding

Natural Sciences and Engineering Research Council of Canada DDG-2019-05754New Brunswick Innovation Foundation M.T. and M.E.S.
6 · The paper itself

Abstract

A novel series of zileuton-hydroxycinnamic acid hybrids were synthesized and screened as 5-lipoxygenase (5-LO) inhibitors in stimulated HEK293 cells and polymorphonuclear leukocytes (PMNL). Zileuton's (

Indexed as

Arachidonate 5-LipoxygenaseComputer SimulationCoumaric AcidsDrug Evaluation, PreclinicalFree Radical ScavengersHEK293 CellsHumansHydroxyureaLipoxygenase InhibitorsMolecular Docking SimulationNeutrophilsStructure-Activity RelationshipArachidonate 5-LipoxygenaseCoumaric AcidsFree Radical ScavengersHydroxyureaLipoxygenase Inhibitorszileuton5-Lipoxygenase inhibitorsanti-leukotrieneshydroxyureainflammationsinapic acidzileuton

Identifiers

PMID33066378
PMCPMC7587396
OpenAlexW3092872856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.