ReviewCells2020
Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms.
Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Sarcopenia in Chronic Heart Failure: Pathophysiology, Clinical Consequences, and Emerging Multimodal Therapeutic Strategies.Nutrients · 2026Review
- Inspiratory Muscle Strength Is an Independent Predictor of Maximum Tongue Pressure in Patients Aged ≥65 Years With Acute Heart Failure - A Retrospective Observational Study.Circulation reports · 2026Article
- Research progress on the diagnosis and pathogenesis of chronic heart failure combined with sarcopenia.Journal of cardiothoracic surgery · 2026Review
- Sarcopenia in chronic obstructive pulmonary disease: mechanisms, diagnosis, and management strategies.Annals of medicine and surgery (2012) · 2025Review
- Exercise and nutrition benefit skeletal muscle: From influence factor and intervention strategy to molecular mechanism.Sports medicine and health science · 2024Review
- Review
- Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity.Clinical interventions in aging · 2024Review
- Improving physical performance reduces dysphagia via improvement of tongue strength in patients with acute heart failure: a two-wave cross-lagged mediation model analysis.Aging clinical and experimental research · 2023Article
- Sarcopenia: An Important Entity Still Underinvestigated in Heart Failure.Arquivos brasileiros de cardiologia · 2023Article
- The role of Huidouba in regulating skeletal muscle metabolic disorders in prediabetic mice through AMPK/PGC-1α/PPARα pathway.Diabetology & metabolic syndrome · 2023Article
- The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease.International journal of molecular sciences · 2023Review
- Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome.Medicina (Kaunas, Lithuania) · 2023Article
- Effects of Resistance Exercise on Slow-Twitch Soleus Muscle of Infarcted Rats.Antioxidants (Basel, Switzerland) · 2023Article
- Depression and risk of sarcopenia: a national cohort and Mendelian randomization study.Frontiers in psychiatry · 2023Article
- Chronic Coronary Syndrome in Frail Old Population.Life (Basel, Switzerland) · 2022Review
- Network pharmacology-based analysis of the effects of puerarin on sarcopenia.Annals of translational medicine · 2022Article
- Serum Meteorin-like is associated with weight loss in the elderly patients with chronic heart failure.Journal of cachexia, sarcopenia and muscle · 2022Article
- Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction.PloS one · 2022Article
- Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology.Frontiers in physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pathogenesis in the aging heart. HF causes diverse metabolic complications that may result in sarcopenia. Therefore, sarcopenia may act as a strong predictor of frailty, disability, and mortality associated with HF. Currently, standard treatments for slowing muscle loss in patients with HF are not available. Therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in HF as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in HF and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.