Evidence map›Paper›PMID 33066210›Full record

ReviewBrain sciences2020

Noise Induced Hearing Loss and Tinnitus-New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention.

Tang-Chuan Wang, Ta-Yuan Chang, Richard Tyler, Ying-Ju Lin, Wen-Miin Liang, Yio-Wha Shau, Wei-Yong Lin, Yi-Wen Chen, Chia-Der Lin, Ming-Hsui Tsai

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Tinnitus: A Dimensionally Segregated, yet Perceptually Integrated Heterogeneous Disorder.Journal of the Association for Research in Otolaryngology : JARO · 2024
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  6. International journal of qualitative studies on health and well-being · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tang-Chuan WangDepartment of Public Health, China Medical University, Taichung City 40402, Taiwan.
Ta-Yuan ChangDepartment of Occupational Safety and Health, China Medical University, Taichung City 40402, Taiwan.ORCID 0000-0001-5664-4559
Richard TylerDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242-1396, USA.
Ying-Ju LinSchool of Chinese Medicine, China Medical University, Taichung City 40402, Taiwan.
Wen-Miin LiangDepartment of Health Services Administration, China Medical University, Taichung City 40402, Taiwan.
Yio-Wha ShauCollege of Biomedical Engineering, China Medical University, Taichung City 40402, Taiwan.
Wei-Yong LinGraduate Institute of Integrated Medicine, China Medical University, Taichung City 40402, Taiwan.ORCID 0000-0002-8443-6180
Yi-Wen ChenGraduate Institute of Biomedical Sciences, China Medical University, Taichung City 40402, Taiwan.
Chia-Der LinSchool of Medicine, China Medical University, Taichung City 40402, Taiwan.
Ming-Hsui TsaiSchool of Medicine, China Medical University, Taichung City 40402, Taiwan.
China Medical University · TWUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the generation of phantom sounds, can also result from noise exposure, although understanding of its underlying mechanisms are limited. Recent studies, however, are shedding light on the neural processes involved in NIHL and tinnitus, leading to potential new and innovative treatments. This review focuses on the assessment of NIHL, available treatments, and development of new pharmacologic and non-pharmacologic treatments based on recent studies of central auditory plasticity and adaptive changes in hearing. We discuss the mechanisms and maladaptive plasticity of NIHL, neuronal aspects of tinnitus triggers, and mechanisms such as tinnitus-associated neural changes at the cochlear nucleus underlying the generation of tinnitus after noise-induced deafferentation. We include observations from recent studies, including our own studies on associated risks and emerging treatments for tinnitus. Increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed. Since no treatment can yet reverse noise-related damage completely, preventative strategies and increased awareness of hearing health are essential.

Indexed as

central auditory systemcochlear damagedeafferentationhidden hearing lossmaladaptive plasticityneural plasticitynoise induced hearing losstinnitus

Identifiers

PMID33066210
PMCPMC7602100
OpenAlexW3092912816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.