Evidence map›Paper›PMID 33066144›Full record

ReviewBrain sciences2020

Olfaction as a Marker for Dystonia: Background, Current State and Directions.

Thorsten Herr, Julie Gamain, Robert Fleischmann, Bernhard Lehnert, Marcus Vollmer, Carsten Willert, Birgitt Veit, Andrea Stenner, Jan-Uwe Mueller, Barbara Caspers and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Thorsten HerrDepartment of Neurology, University Medicine Greifswald, Fleischmannstraße 8, 17475 Greifswald, Germany.
Julie GamainDepartment of Neurology, University Medicine Greifswald, Fleischmannstraße 8, 17475 Greifswald, Germany.
Robert FleischmannDepartment of Neurology, University Medicine Greifswald, Fleischmannstraße 8, 17475 Greifswald, Germany.ORCID 0000-0001-8159-2658
Bernhard LehnertDepartment of Otorhinolaryngology, University Medicine Greifswald, Fleischmannstraße 8, 17475 Greifswald, Germany.
Marcus VollmerInstitute of Bioinformatics, University Medicine Greifswald, Felix-Hausdorff-Str. 8, 17475 Greifswald, Germany.ORCID 0000-0002-4593-2026
Carsten WillertNeurology Group Practice, Bleistraße 13, 18439 Stralsund, Germany.
Birgitt VeitNeurology Group Practice, An der Marienkirche 2, 17033 Neubrandenburg, Germany.
Andrea StennerOutpatient Department of Neurology, Movement Disorders Competence Center, Paracelsus Hospital Zwickau, Werdauer Straße 68, 08060 Zwickau, Germany.
Jan-Uwe MuellerDepartment of Neurosurgery, University Medicine Greifswald, Fleischmannstraße 8, 17475 Greifswald, Germany.
Barbara CaspersDepartment of Behavioural Ecology, University of Bielefeld, Konsequenz 45, 33615 Bielefeld, Germany.
Martin KronenbuergerDepartment of Neurology, University Medicine Greifswald, Fleischmannstraße 8, 17475 Greifswald, Germany.
Universitätsmedizin Greifswald · DEBielefeld University · DEJohns Hopkins University · USParacelsus-Kliniken · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dystonia is a heterogeneous group of hyperkinetic movement disorders. The unifying descriptor of dystonia is the motor manifestation, characterized by continuous or intermittent contractions of muscles that cause abnormal movements and postures. Additionally, there are psychiatric, cognitive, and sensory alterations that are possible or putative non-motor manifestations of dystonia. The pathophysiology of dystonia is incompletely understood. A better understanding of dystonia pathophysiology is highly relevant in the amelioration of significant disability associated with motor and non-motor manifestations of dystonia. Recently, diminished olfaction was found to be a potential non-motor manifestation that may worsen the situation of subjects with dystonia. Yet, this finding may also shed light into dystonia pathophysiology and yield novel treatment options. This article aims to provide background information on dystonia and the current understanding of its pathophysiology, including the key structures involved, namely, the basal ganglia, cerebellum, and sensorimotor cortex. Additionally, involvement of these structures in the chemical senses are reviewed to provide an overview on how olfactory (and gustatory) deficits may occur in dystonia. Finally, we describe the present findings on altered chemical senses in dystonia and discuss directions of research on olfactory dysfunction as a marker in dystonia.

Indexed as

basal gangliacerebellumchemical sensesnetworknon-motor manifestationsensorimotor cortexsocial interactionstaste

Identifiers

PMID33066144
PMCPMC7601998
OpenAlexW3092840253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.