Evidence map›Paper›PMID 33066085›Full record

ReviewMicromachines2020

Ultrasonic Retinal Neuromodulation and Acoustic Retinal Prosthesis.

Pei-An Lo, Kyana Huang, Qifa Zhou, Mark S Humayun, Lan Yue

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Ultrasound stimulation for non-invasive visual prostheses.Frontiers in cellular neuroscience · 2022
    Review
  5. Neuromodulation using electroosmosis.Journal of neural engineering · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pei-An LoRoski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Kyana HuangRoski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Qifa ZhouRoski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Mark S HumayunRoski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Lan YueRoski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Dean's Pilot Funding Program, USC, Los Angeles, CA NAGinsburg Institute for Biomedical Therapeutics, USC, Los Angeles, CA NANEI NIH HHS P30 EY029220NSF Biophotonics 1805210NSF EAGER 1833288Unrestricted Grant to the Department of Ophthalmology from Research to Prevent Blindness, New York, NY NA
6 · The paper itself

Abstract

Ultrasound is an emerging method for non-invasive neuromodulation. Studies in the past have demonstrated that ultrasound can reversibly activate and inhibit neural activities in the brain. Recent research shows the possibility of using ultrasound ranging from 0.5 to 43 MHz in acoustic frequency to activate the retinal neurons without causing detectable damages to the cells. This review recapitulates pilot studies that explored retinal responses to the ultrasound exposure, discusses the advantages and limitations of the ultrasonic stimulation, and offers an overview of engineering perspectives in developing an acoustic retinal prosthesis. For comparison, this article also presents studies in the ultrasonic stimulation of the visual cortex. Despite that, the summarized research is still in an early stage; ultrasonic retinal stimulation appears to be a viable technology that exhibits enormous therapeutic potential for non-invasive vision restoration.

Indexed as

neuromodulationneurostimulationretinaultrasoundvisual restoration

Identifiers

PMID33066085
PMCPMC7600354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.