Evidence map›Paper›PMID 33066038›Full record

ArticleInternational journal of molecular sciences2020

Constant Light Dysregulates Cochlear Circadian Clock and Exacerbates Noise-Induced Hearing Loss.

Chao-Hui Yang, Chung-Feng Hwang, Jiin-Haur Chuang, Wei-Shiung Lian, Feng-Sheng Wang, Ethan I Huang, Ming-Yu Yang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chao-Hui YangDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0003-4055-1686
Chung-Feng HwangDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Jiin-Haur ChuangGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan 33302, Taiwan.
Wei-Shiung LianCore Laboratory for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Feng-Sheng WangGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan 33302, Taiwan.
Ethan I HuangDepartment of Otolaryngology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Ming-Yu YangDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0002-6841-5478
Chang Gung University · TWChiayi Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital CMRPG8E1481, CMRPG8E1482, CMRPG8E1483 & CMRPG8G1101Ministry of Science and Technology MOST 107-2314-B-182A-083- & MOST 109-2314-B-182A-016
6 · The paper itself

Abstract

Noise-induced hearing loss is one of the major causes of acquired sensorineural hearing loss in modern society. While people with excessive exposure to noise are frequently the population with a lifestyle of irregular circadian rhythms, the effects of circadian dysregulation on the auditory system are still little known. Here, we disturbed the circadian clock in the cochlea of male CBA/CaJ mice by constant light (LL) or constant dark. LL significantly repressed circadian rhythmicity of circadian clock genes

Indexed as

LightAnimalsARNTL Transcription FactorsAuditory ThresholdCircadian ClocksCLOCK ProteinsCochleaEvoked Potentials, Auditory, Brain StemHearing Loss, Noise-InducedMaleMiceMice, Inbred CBANuclear Receptor Subfamily 1, Group D, Member 1Period Circadian ProteinsARNTL Transcription FactorsBmal1 protein, mouseCLOCK ProteinsNuclear Receptor Subfamily 1, Group D, Member 1Per1 protein, mousePer2 protein, mousePeriod Circadian Proteinscircadian dysregulationclock genesnoise-induced hearing losssensory hair cellssynaptic ribbons

Identifiers

PMID33066038
PMCPMC7589695
OpenAlexW3092777311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.