Evidence map›Paper›PMID 33065978›Full record

ArticleInsects2020

High-Throughput Genotyping of Common Chromosomal Inversions in the Afrotropical Malaria Mosquito

Martin Lukindu, R Rebecca Love, Moussa W Guelbeogo, Scott T Small, Melissa T Stephens, Nathan R Campbell, N'Fale Sagnon, Carlo Costantini, Nora J Besansky

Open access · goldAbstract read
In one paragraph

Article in Insects, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Genomic signatures of selection inbioRxiv : the preprint server for biology · 2026
    Article
  2. Chromosomal inversions and their impact on insect evolution.Current opinion in insect science · 2024
    Review
  3. Review
  4. Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Martin LukinduEck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
R Rebecca LoveEck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-8725-3929
Moussa W GuelbeogoCentre National de Recherche et Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.
Scott T SmallEck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
Melissa T StephensDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Nathan R CampbellGTseek LLC, Twin Falls, ID 83301, USA.
N'Fale SagnonCentre National de Recherche et Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.
Carlo CostantiniCentre National de Recherche et Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.ORCID 0000-0003-1016-129X
Nora J BesanskyEck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
University of Notre Dame · USCentre National de Recherche et de Formation sur le Paludisme · BFCentre National de la Recherche Scientifique · FR

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Empowering functional genomics of An. gambiae through inversion genotypingR01AI125360 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2017 to 2021
$2.5M
Elucidating the An. Funestus complexR21AI123491 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2016 to 2017
$437k
Bill and Melinda Gates Foundation Target MalariaNCI NIH HHS NIH 5 P30 CA06516NIAID NIH HHS R01 AI125360NIAID NIH HHS R21 AI123491NIH HHS R01 AI125360Open Philanthropy Project Target Malaria
6 · The paper itself

Abstract

Polymorphic chromosomal inversions have been implicated in local adaptation. In anopheline mosquitoes, inversions also contribute to epidemiologically relevant phenotypes such as resting behavior. Progress in understanding these phenotypes and their mechanistic basis has been hindered because the only available method for inversion genotyping relies on traditional cytogenetic karyotyping, a rate-limiting and technically difficult approach that is possible only for the fraction of the adult female population at the correct gonotrophic stage. Here, we focus on an understudied malaria vector of major importance in sub-Saharan Africa,

Indexed as

Anopheles funestuschromosomal inversion polymorphisminversion genotypingkaryotypingmalaria vectorpolytene chromosome analysistag SNP

Identifiers

PMID33065978
PMCPMC7650614
OpenAlexW3092100798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.