Evidence map›Paper›PMID 33065764›Full record

ArticleEuropean journal of immunology2021

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.

Matthijs J D Baars, Thera Douma, Dimitre R Simeonov, Darienne R Myers, Kayla Kulhanek, Saikat Banerjee, Susan Zwakenberg, Marijke P Baltissen, Mojtaba Amini, Sytze de Roock and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Dissecting PGENature communications · 2026
    Article
  2. Article
  3. [Prediction of immunotherapy targets for chronic cerebral hypoperfusion by bioinformatics method].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. [Development of autoimmunity in patients with primary immunodeficiencies].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Matthijs J D BaarsMolecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Thera DoumaCenter of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Dimitre R SimeonovDiabetes Center, University of California San Francisco, San Francisco, CA, USA.
Darienne R MyersBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Kayla KulhanekDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Saikat BanerjeeDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Susan ZwakenbergMolecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Marijke P BaltissenDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Mojtaba AminiMolecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Sytze de RoockPediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Femke van WijkCenter of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Michiel VermeulenDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Alexander MarsonDiabetes Center, University of California San Francisco, San Francisco, CA, USA.
Jeroen P RooseDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Yvonne VercoulenMolecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-5060-2603
Utrecht University · NLUniversity of California, San Francisco · USRadboud University Nijmegen · NLGladstone Institutes · US

Funding

Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEROEN ROOSE · 2011 to 2026
$31.1M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Functional Interrogation of Non-Coding Type 1 Diabetes Risk Variants in Human Immune Cells and Beta CellsDP3DK111914 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSON, ALEXANDER · 2016 to 2016
$3.7M
Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling VariantsR01AI104789 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROOSE, JEROEN · 2014 to 2018
$1.9M
Functional Molecular Investigation of Inflammatory Bowel Disease (IBD) Risk VariantsR01DK119979 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSON, ALEXANDER · 2018 to 2021
$671k
Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling VariantsR56AI104789 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROOSE, JEROEN · 2021 to 2021
$242k
Cancer Research InstituteNIAID NIH HHS P01 AI091580NIAID NIH HHS R01 AI104789NIAID NIH HHS R56 AI104789NIDDK NIH HHS DP3 DK111914NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK119979
6 · The paper itself

Abstract

RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1-deficient patients suffer from immune deficiency, and the RASGRP1 gene has been linked to autoimmunity. However, how RasGRP1 levels are regulated, and if RasGRP1 dosage alterations contribute to autoimmunity remains unknown. We demonstrate that diminished Rasgrp1 expression caused defective T lymphocyte selection in C57BL/6 mice, and that the severity of inflammatory disease inversely correlates with Rasgrp1 expression levels. In patients with autoimmunity, active inflammation correlated with decreased RASGRP1 levels in CD4

Indexed as

AnimalsAutoimmunityCD4-Positive T-LymphocytesCore Binding Factor Alpha 2 SubunitCRISPR-Cas SystemsDNA-Binding ProteinsGene Expression RegulationGuanine Nucleotide Exchange FactorsHistonesHumansInflammationMiceMice, Inbred C57BLMice, KnockoutTranscription, GeneticCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsGuanine Nucleotide Exchange FactorsHistonesRASGRP1 protein, humanRUNX1 protein, humanautoimmunityRASGRP1RUNX1T cellstranscription

Identifiers

PMID33065764
PMCPMC7894479
OpenAlexW3093025781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.