ArticleCortex; a journal devoted to the study of the nervous system and behavior2020
Age differences in predicting working memory performance from network-based functional connectivity.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Multimodal MRI prediction of cognitive functioning across the lifespan: separating between-person differences from within-person changes.GeroScience · 2026Article
- Prediction of cognitive test scores: a comparison of brain structure, health, demographic, and cognitive data across adulthood.GeroScience · 2026Article
- Hippocampal and prefrontal GABA and glutamate concentration contribute to component processes of working memory in aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Prediction of Verbal Abilities From Brain Connectivity Data Across the Lifespan Using a Machine Learning Approach.Human brain mapping · 2025Article
- Novel Genes Associated With Working Memory Are Identified by Combining Connectome, Transcriptome, and Genome.Human brain mapping · 2025Article
- Individual characteristics outperform resting-state fMRI for the prediction of behavioral phenotypes.Communications biology · 2024Article
- Network and state specificity in connectivity-based predictions of individual behavior.Human brain mapping · 2024Article
- Sex classification from functional brain connectivity: Generalization to multiple datasets.Human brain mapping · 2024Article
- Sex classification from functional brain connectivity: Generalization to multiple datasets Generalizability of sex classifiers.bioRxiv : the preprint server for biology · 2024Article
- Prediction of cognitive performance differences in older age from multimodal neuroimaging data.GeroScience · 2024Article
- Network and State Specificity in Connectivity-Based Predictions of Individual Behavior.bioRxiv : the preprint server for biology · 2023Article
- Predicting executive functioning from brain networks: modality specificity and age effects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain functional characterization of response-code conflict in dual-tasking and its modulation by age.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The challenges and prospects of brain-based prediction of behaviour.Nature human behaviour · 2023Review
- Predicting Executive Functioning from Brain Networks: Modality Specificity and Age Effects.bioRxiv : the preprint server for biology · 2023Article
- Predicting executive functioning from functional brain connectivity: network specificity and age effects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spectrotemporal content of human auditory working memory represented in functional connectivity patterns.Communications biology · 2023Article
- Classification and prediction of cognitive performance differences in older age based on brain network patterns using a machine learning approach.Network neuroscience (Cambridge, Mass.) · 2023Article
- Cross-cohort replicability and generalizability of connectivity-based psychometric prediction patterns.NeuroImage · 2022Article
- Functional Imaging to Guide Network-Based TMS Treatments: Toward a Tailored Medicine Approach in Alzheimer's Disease.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Deterioration in working memory capacity (WMC) has been associated with normal aging, but it remains unknown how age affects the relationship between WMC and connectivity within functional brain networks. We therefore examined the predictability of WMC from fMRI-based resting-state functional connectivity (RSFC) within eight meta-analytically defined functional brain networks and the connectome in young and old adults using relevance vector machine in a robust cross-validation scheme. Particular brain networks have been associated with mental functions linked to WMC to a varying degree and are associated with age-related differences in performance. Comparing prediction performance between the young and old sample revealed age-specific effects: In young adults, we found a general unpredictability of WMC from RSFC in networks subserving WM, cognitive action control, vigilant attention, theory-of-mind cognition, and semantic memory, whereas in older adults each network significantly predicted WMC. Moreover, both WM-related and WM-unrelated networks were differently predictive in older adults with low versus high WMC. These results indicate that the within-network functional coupling during task-free states is specifically related to individual task performance in advanced age, suggesting neural-level reorganization. In particular, our findings support the notion of a decreased segregation of functional brain networks, deterioration of network integrity within different networks and/or compensation by reorganization as factors driving associations between individual WMC and within-network RSFC in older adults. Thus, using multivariate pattern regression provided novel insights into age-related brain reorganization by linking cognitive capacity to brain network integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.