ArticleNeuroImage. Clinical2020
Effects of simultaneous real-time fMRI and EEG neurofeedback in major depressive disorder evaluated with brain electromagnetic tomography.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effects of neurofeedback on major depressive disorder: a systematic review.Einstein (Sao Paulo, Brazil) · 2023Pooled it
- Simultaneous real-time EEG-fMRI neurofeedback: A systematic review.Frontiers in human neuroscience · 2023Pooled it
- Neurofeedback in Major Depression.Advances in experimental medicine and biology · 2026Review
- Neural mechanisms underlying implicit emotion regulation deficit in relational and nonrelational trauma PTSD: Insights from the Nested Hierarchical Model of Self.Psychological medicine · 2025Article
- The characteristics of anhedonia in depression: a review from a clinically oriented perspective.Translational psychiatry · 2025Review
- Evaluating the effects of multimodal EEG-fNIRS neurofeedback for motor imagery: An experimental platform and study protocol.PloS one · 2025Article
- Evaluation of Theta EEG Neurofeedback Procedure for Cognitive Training Using Simultaneous fMRI in Counterbalanced Active-Sham Study Design.Human brain mapping · 2025Article
- Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD).Molecular neurobiology · 2024Review
- Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study.Neuropsychiatric disease and treatment · 2024Article
- Article
- EEG-LLAMAS: A low-latency neurofeedback platform for artifact reduction in EEG-fMRI.NeuroImage · 2023Article
- Exposure to nature is associated with decreased functional connectivity within the distress network: A resting state EEG study.Frontiers in psychology · 2023Article
- Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies.Reviews in endocrine & metabolic disorders · 2022Review
- Simultaneous EEG-fMRI: What Have We Learned and What Does the Future Hold?Sensors (Basel, Switzerland) · 2022Review
- Editorial: Clinical Neurofeedback.NeuroImage. Clinical · 2022Article
- Affective Neurofeedback Under Naturalistic Conditions: A Mini-Review of Current Achievements and Open Challenges.Frontiers in neuroergonomics · 2021Review
- fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation.Frontiers in psychiatry · 2021Article
- The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review.Neural plasticity · 2021Review
- Emotion self-regulation training in major depressive disorder using simultaneous real-time fMRI and EEG neurofeedback.NeuroImage. Clinical · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, we reported an emotion self-regulation study (Zotev et al., 2020), in which patients with major depressive disorder (MDD) used simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) to upregulate two fMRI and two EEG activity measures, relevant to MDD. The target measures included fMRI activities of the left amygdala and left rostral anterior cingulate cortex, and frontal EEG asymmetries in the alpha band (FAA) and high-beta band (FBA). Here we apply the exact low resolution brain electromagnetic tomography (eLORETA) to investigate EEG source activities during the rtfMRI-EEG-nf procedure. The exploratory analyses reveal significant changes in hemispheric lateralities of upper alpha and high-beta current source densities in the prefrontal regions, consistent with upregulation of the FAA and FBA during the rtfMRI-EEG-nf task. Similar laterality changes are observed for current source densities in the amygdala. Prefrontal upper alpha current density changes show significant negative correlations with anhedonia severity. Changes in prefrontal high-beta current density are consistent with reduction in comorbid anxiety. Comparisons with results of previous LORETA studies suggest that the rtfMRI-EEG-nf training is beneficial to MDD patients, and may have the ability to correct functional deficiencies associated with anhedonia and comorbid anxiety in MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.