Evidence map›Paper›PMID 33065466›Full record

ArticleUltrasonics2021

Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.

Xuejun Qian, Runze Li, Gengxi Lu, Laiming Jiang, Haochen Kang, K Kirk Shung, Mark S Humayun, Qifa Zhou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

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  10. Quantitative Optical Coherence Elastography of the Optic Nerve Head In Vivo.IEEE transactions on bio-medical engineering · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xuejun QianDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA; USC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Runze LiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA; USC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Gengxi LuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA; USC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Laiming JiangUSC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Haochen KangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
K Kirk ShungDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Mark S HumayunDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA; USC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA.
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA; USC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: qifazhou@usc.edu.
University of Southern California · USSouthern California Eye Institute · US

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Non-invasive Ultrasound Stimulated Retinal ProsthesisR01EY030126 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2019 to 2022
$2.0M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY026091NEI NIH HHS R01 EY028662NEI NIH HHS R01 EY030126
6 · The paper itself

Abstract

purposeTo quantitatively investigate both optic nerve head (ONH) and peripapillary sclera (PPS) biomechanical properties of porcine eyes through an ultrasonic elastography imaging system in response to both increasing and decreasing intraocular pressure (IOP).

methodsThe Young's modulus of the ONH and PPS were assessed using our high resolution ultrasonic imaging system which utilized a mechanical shaker to induce shear waves and an off-axis aligned 40 MHz needle transducer to track micron-level displacement along the direction of wave propagation. In this study, imaging on a total of 8 ex vivo porcine eyes preloaded with IOPs from 6 mmHg to 30 mmHg was performed. To have a better understanding of the effect of varying IOP on biomechanics, both increasing and decreasing IOPs were investigated.

resultsThe increase of the Young's modulus of ONH (92.4 ± 13.9 kPa at 6 mmHg to 224.7 ± 71.1 kPa at 30 mmHg) and PPS (176.8 ± 14.3 kPa at 6 mmHg to 573.5 ± 64.4 kPa at 30 mmHg) following IOP elevation could be observed in the reconstructed Young's modulus of the shear wave elasticity (SWE) imaging while the B-mode structural images remained almost unchanged. In addition, for the same IOP level, both ONH and PPS have a tendency to be stiffer with decreasing IOP as compared to increasing IOP.

conclusionsOur results demonstrate the feasibility of using our ultrasonic elastography system to investigate the stiffness mapping of posterior eye with high resolution in both increasing and decreasing IOPs, making this technique potentially useful for glaucoma.

Indexed as

AnimalsBiomechanical PhenomenaElasticity Imaging TechniquesElastic ModulusEquipment DesignGlaucomaIn Vitro TechniquesOptic DiskPhantoms, ImagingScleraSwineGlaucomaHigh frequency ultrasound elastographyOptic nerve headPeripapillary scleraShear wave propagation

Identifiers

PMID33065466
PMCPMC7736296
OpenAlexW3092321536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.