ArticleAnnals of epidemiology2021
A comparison of childhood asthma case definitions based on parent-reported data.
Article in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Nasopharyngeal Microbiome-Epigenome-Wide Association Analysis in Infants With Severe Bronchiolitis.Allergy · 2026Article
- Impact of varying childhood asthma definitions on incidence and clinical outcomes.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.The European respiratory journal · 2024Article
- Lower socioeconomic status may help explain racial disparities in asthma and atopic dermatitis prevalence: A mediation analysis.The Journal of allergy and clinical immunology · 2024Article
- Chlorinated pool exposure, allergic sensitization, and risk of age 5-year asthma.Pediatric research · 2023Article
- Application of Asthma Prediction Tools in a Cohort of Infants with Severe Bronchiolitis.Pediatric allergy, immunology, and pulmonology · 2023Article
- Recurrent wheezing phenotypes after severe bronchiolitis and progression to asthma.The journal of allergy and clinical immunology. Global · 2023Article
- Association between Asthma and Suicidality in 9-12-Year-Old Youths.Brain sciences · 2022Article
- Infant Exposure to Acid Suppressant Medications Increases Risk of Recurrent Wheeze and Asthma in Childhood.The journal of allergy and clinical immunology. In practice · 2022Article
- Late Pre-term Infants with Severe Bronchiolitis and Risk of Asthma by Age 5 Years.The Journal of pediatrics · 2022Article
- Proximity to Major Roads and Risks of Childhood Recurrent Wheeze and Asthma in a Severe Bronchiolitis Cohort.International journal of environmental research and public health · 2021Article
- Performance of Three Asthma Predictive Tools in a Cohort of Infants Hospitalized With Severe Bronchiolitis.Frontiers in allergy · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to compare research definitions of childhood asthma based on parent-reported data.
methodsWe conducted a multicenter, prospective cohort study of 921 infants hospitalized for bronchiolitis. Follow-up was conducted via biannual parent interviews. Asthma definitions were developed using parent-reported data: clinician diagnosis by the age of 5 years ("broad definition"), clinician diagnosis by the age of 5 years with either asthma medication use or asthma symptoms during the age of 4-4.9 years ("epidemiologic definition"), clinician diagnosis by the age of 5 years with either long-term inhaled corticosteroid use or asthma symptoms during the age of 4-4.9 years ("strict definition"), and a "flexible definition" met by any two of the three criteria in the epidemiologic definition. Asthma outcome definitions were evaluated using unadjusted associations with known major asthma risk factors and validated against the medical record in a subset (n = 116).
resultsAsthma prevalence for the broad definition was 294 of 875 (34%); epidemiologic definition, 235 of 859 (27%); strict definition, 229 of 859 (27%); and flexible definition, 364 of 826 (44%). Risk factors had similarly strong associations with definitions that required clinician diagnosis and weaker associations with the flexible definition. The epidemiologic and strict definitions had the highest specificity (96%) and positive predictive value (92%).
conclusionsThe parent report of clinician-diagnosed asthma correlates well with known asthma risk factors.
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