Evidence map›Paper›PMID 33065046›Full record

ReviewStem cell reports2020

Basal-like Progenitor Cells: A Review of Dysplastic Alveolar Regeneration and Remodeling in Lung Repair.

Maria Fernanda de Mello Costa, Aaron I Weiner, Andrew E Vaughan

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Autologous transplantation of P63Cell reports. Medicine · 2024
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Influenza-induced tuft cell expansion alters ILC-mediated inflammation.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Scar wars: the viral menace.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  17. Review
  18. Article
  19. Review
  20. From Epithelium to Therapy: Transitional Cells in Lung Fibrosis.American journal of respiratory cell and molecular biology · 2025
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maria Fernanda de Mello CostaSchool of Veterinary Medicine, Department of Biomedical Sciences, The University of Pennsylvania, 3800 Spruce Street, Philadelphia, USA; Institute for Regenerative Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, USA.
Aaron I WeinerSchool of Veterinary Medicine, Department of Biomedical Sciences, The University of Pennsylvania, 3800 Spruce Street, Philadelphia, USA; Perelman School of Medicine, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, USA; Institute for Regenerative Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, USA.
Andrew E VaughanSchool of Veterinary Medicine, Department of Biomedical Sciences, The University of Pennsylvania, 3800 Spruce Street, Philadelphia, USA; Institute for Regenerative Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, USA. Electronic address: andrewva@vet.upenn.edu.
California Institute for Regenerative Medicine · US

Funding

Solitary chemosensory / tuft cells in lung regeneration and inflammationR01HL153539 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2020 to 2024
$2.0M
NHLBI NIH HHS R01 HL153539
6 · The paper itself

Abstract

Despite the central importance of the respiratory system, the exact mechanisms governing lung repair after severe injury remain unclear. The notion that alveolar type 2 cells (AT2s) self-renew and differentiate into alveolar type 1 cells (AT1s) does not fully encompass scenarios where these progenitors are severely affected by disease, e.g., H1N1 influenza or SARS-CoV-2 (COVID-19). Intrapulmonary p63

Indexed as

RegenerationAlveolar Epithelial CellsCell DifferentiationCOVID-19HumansLungLung DiseasesSARS-CoV-2Stem CellsStem Cell Transplantationbasal cellsepithelial cellsinfluenzaintrapulmonary p63(+) progenitor cellskeratin 5respiratory systemreview

Identifiers

PMID33065046
PMCPMC7560757
OpenAlexW3093315785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.