Evidence map›Paper›PMID 33064972›Full record

ArticleGut microbes2020

Conserved anti-inflammatory effects and sensing of butyrate in zebrafish.

Pradeep Manuneedhi Cholan, Alvin Han, Brad R Woodie, Maxinne Watchon, Angela Rm Kurz, Angela S Laird, Warwick J Britton, Lihua Ye, Zachary C Holmes, Jessica R McCann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 94 citations in OpenAlex.

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  13. The Role of Short Chain Fatty Acids in Inflammation and Body Health.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Pradeep Manuneedhi CholanTuberculosis Research Program at the Centenary Institute, The University of Sydney , Camperdown, Australia.
Alvin HanDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine , Durham, NC, USA.
Brad R WoodieTuberculosis Research Program at the Centenary Institute, The University of Sydney , Camperdown, Australia.
Maxinne WatchonCentre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Macquarie Park, Australia.
Angela Rm KurzCentenary Imaging and Sydney Cytometry at the Centenary Institute, The University of Sydney , Camperdown, Australia.ORCID 0000-0002-5032-8026
Angela S LairdCentre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Macquarie Park, Australia.ORCID 0000-0002-6860-9192
Warwick J BrittonTuberculosis Research Program at the Centenary Institute, The University of Sydney , Camperdown, Australia.ORCID 0000-0001-6721-9646
Lihua YeDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine , Durham, NC, USA.ORCID 0000-0001-6790-9743
Zachary C HolmesDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine , Durham, NC, USA.
Jessica R McCannDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine , Durham, NC, USA.
Lawrence A DavidDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine , Durham, NC, USA.ORCID 0000-0002-3570-4767
John F RawlsDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine , Durham, NC, USA.
Stefan H OehlersTuberculosis Research Program at the Centenary Institute, The University of Sydney , Camperdown, Australia.ORCID 0000-0003-0260-672X
Duke University · USThe University of Sydney · AUMacquarie University · AU

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Role of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SARTOR, RYAN B · 2013 to 2023
$17.9M
NCI NIH HHS P30 CA014236NIDDK NIH HHS P01 DK094779
6 · The paper itself

Abstract

Short-chain fatty acids (SCFAs) are produced by microbial fermentation of dietary fiber in the gut. Butyrate is a particularly important SCFA with anti-inflammatory properties and is generally present at lower levels in inflammatory diseases associated with gut microbiota dysbiosis in mammals. We aimed to determine if SCFAs are produced by the zebrafish microbiome and if SCFAs exert conserved effects on zebrafish immunity as an example of the non-mammalian vertebrate immune system. We demonstrate that bacterial communities from adult zebrafish intestines synthesize all three main SCFA

Indexed as

AcetatesAnimalsAnti-Inflammatory AgentsButyratesDietary FiberDysbiosisGastrointestinal MicrobiomeMacrophagesMaleNeutrophilsPropionatesReceptors, G-Protein-CoupledWounds and InjuriesZebrafishAcetatesAnti-Inflammatory AgentsButyratesDietary FiberPropionatesReceptors, G-Protein-Coupledbutyrateinflammationmacrophageneutrophilshort-chain fatty acidtumor necrosis factorZebrafish

Identifiers

PMID33064972
PMCPMC7575005
OpenAlexW3092987617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.