ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2021
Early-life stress influences ion balance in developing zebrafish (Danio rerio).
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Trade-offs between ionic regulation and hypoxia tolerance in zebrafish (Danio rerio) raised in a low pH environment.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- The number of conspecific alarm substance donors notably influences the behavioural responses of zebrafish subjected to a traumatic stress procedure.Fish physiology and biochemistry · 2025Article
- Early-life challenge enhances cortisol regulation in zebrafish larvae.Biology open · 2024Article
- Cortisol dynamics and GR-dependent feedback regulation in zebrafish larvae exposed to repeated stress.Biology open · 2024Article
- Knock-out of vasotocin reduces reproductive success in female zebrafish,Frontiers in endocrinology · 2023Article
- Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a key endocrine axis involved in responding to stress, the hypothalamic-pituitary-interrenal axis plays dual roles in mobilizing energy and maintaining ionic/osmotic balance in fishes. Although these roles have been examined independently in detail in adult fishes, less attention has been paid to the effects of an endogenous stress response during early life, particularly with respect to its potential effects on ionic/osmotic balance. The present study tested the hypothesis that exposure of zebrafish to stress during early development would alter ion balance later in life. Zebrafish at three developmental stages (4, 7, or 15 days post-fertilization, dpf) were subjected to an air-exposure stressor twice a day for 2 days, causing elevation of whole-body cortisol levels. Individuals stressed early in life exhibited decreased survival and growth, altered cortisol responses to a subsequent air-exposure stressor, and increased whole-body Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.