Evidence map›Paper›PMID 33064187›Full record

ArticleApplied microbiology and biotechnology2020

Metabolic engineering of Escherichia coli for polyamides monomer δ-valerolactam production from feedstock lysine.

Yanqin Xu, Dan Zhou, Ruoshi Luo, Xizhi Yang, Baosheng Wang, Xiaochao Xiong, Weifeng Shen, Dan Wang, Qinhong Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yanqin XuDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.
Dan ZhouDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.
Ruoshi LuoDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.
Xizhi YangDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.
Baosheng WangDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.
Xiaochao XiongDepartment of Biological Systems Engineering, Washington State University, Pullman, WA, 99164-6120, USA.
Weifeng ShenDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China.
Dan WangDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, Chongqing University, Chongqing, 401331, People's Republic of China. dwang@cqu.edu.cn.ORCID http://orcid.org/0000-0002-8529-1665
Qinhong WangKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. wang_qh@tib.cas.cn.
Chongqing University · CNChinese Academy of Sciences · CNWashington State University · US

Funding

Fundamental Research Funds for the Central Universities 106112017CDJXFLX0014, 2018CDQYHG0010National Natural Science Foundation of China 21978027
6 · The paper itself

Abstract

Nylon 5 and nylon 6,5 are recently explored as new commercial polyamides, of which the monomer includes δ-valerolactam. In this study, a novel catalytic activity of lysine 2-monooxygenase (DavB) was explored to produce δ-valerolactam from L-pipecolic acid (L-PA), functioning as oxidative decarboxylase on a cyclic compound. Recombinant Escherichia coli BS01 strain expressing DavB from Pseudomonas putida could synthesize δ-valerolactam from L-pipecolic acid with a concentration of 90.3 mg/L. Through the co-expression of recombinant apoptosis-inducing protein (rAIP) from Scomber japonicus, glucose dehydrogenase (GDH) from Bacillus subtilis, Δ

Indexed as

Escherichia coliMetabolic EngineeringLysineNylonsPiperidones2-piperidoneLysineNylonsPiperidonesBio-nylonLysine 2-monooxygenaseMicrobial conversionSubstrate promiscuityδ-Valerolactam

Identifiers

PMID33064187
OpenAlexW3093463132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.