Evidence map›Paper›PMID 33064098›Full record

ArticleJournal of participatory medicine2020

Methicillin-Resistant Staphylococcus aureus Eradication and Decolonization in Children Study (Part 2): Patient- and Parent-Centered Outcomes of Decolonization.

Courtney M Moore, Sarah E Wiehe, Dustin O Lynch, Gina Em Claxton, Matthew P Landman, Aaron E Carroll, Paul I Musey

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of participatory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02127658 (MRSA Eradication and Decolonization in Children), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02127658 phase4terminatednot on this map

MRSA Eradication and Decolonization in Children

TypeinterventionalSponsorIndiana UniversityRan2016 to 2020Enrolled14ConditionsMRSAArmsHygiene education, Sodium Hypochlorite, Mupirocin ointment
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Courtney M Moore *Research Jam, The Indiana Clinical and Translational Sciences Institute, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0003-3563-0259
Sarah E Wiehe *Research Jam, The Indiana Clinical and Translational Sciences Institute, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0002-8148-0848
Dustin O Lynch *Research Jam, The Indiana Clinical and Translational Sciences Institute, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0003-1356-1192
Gina Em Claxton *Research Jam, The Indiana Clinical and Translational Sciences Institute, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0002-5494-2170
Matthew P Landman *Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0003-0441-5329
Aaron E Carroll *Pediatric and Adolescent Comparative Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0002-2699-4707
Paul I Musey *Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0002-5693-190X
Indiana Clinical and Translational Sciences Institute · USIndiana University School of Medicine

Funding

Improving Patient-Centered Outcomes Research in Pediatric SubspecialitiesR24HS022434 · AHRQ · INDIANA UNIVERSITY INDIANAPOLIS · PI CARROLL, AARON E. · 2013 to 2017
$4.8M
Indiana Clinical and Translational Sciences InstituteTL1TR001107 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$2.0M
AHRQ HHS R24 HS022434NCATS NIH HHS TL1 TR001107
6 · The paper itself

Abstract

backgroundSkin and soft tissue infections (SSTIs) due to community-acquired methicillin-resistant Staphylococcus aureus (MRSA) can lead to a number of significant known medical outcomes including hospitalization, surgical procedures such as incision and drainage (I&D), and the need for decolonization procedures to remove the bacteria from the skin and nose and prevent recurrent infection. Little research has been done to understand patient and caregiver-centered outcomes associated with the successful treatment of MRSA infection.

objectiveThis study aimed to uncover MRSA decolonization outcomes that are important to patients and their parents in order to create a set of prototype measures for use in the MRSA Eradication and Decolonization in Children (MEDiC) study.

methodsA 4-hour, human-centered design (HCD) workshop was held with 5 adolescents (aged 10-18 years) who had experienced an I&D procedure and 11 parents of children who had experienced an I&D procedure. The workshop explored the patient and family experience with skin infection to uncover patient-centered outcomes of MRSA treatment. The research team analyzed the audio and artifacts created during the workshop and coded for thematic similarity. The final themes represent patient-centered outcome domains to be measured in the MEDiC comparative effectiveness trial.

resultsThe workshop identified 9 outcomes of importance to patients and their parents: fewer MRSA outbreaks, improved emotional health, improved self-perception, decreased social stigma, increased amount of free time, increased control over free time, fewer days of school or work missed, decreased physical pain and discomfort, and decreased financial burden.

conclusionsThis study represents an innovative HCD approach to engaging patients and families with lived experience with MRSA SSTIs in the study design and trial development to determine meaningful patient-centered outcomes. We were able to identify 9 major recurrent themes. These themes were used to develop the primary and secondary outcome measures for MEDiC, a prospectively enrolling comparative effectiveness trial.

trial registrationClinicalTrials.gov NCT02127658; https://clinicaltrials.gov/ct2/show/NCT02127658.

Indexed as

abscessdecolonizationhuman-centered designpatient-centered outcomesStaphylococcus aureus

Identifiers

PMID33064098
PMCPMC7434081
OpenAlexW3007581054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.