Evidence map›Paper›PMID 33064079›Full record

ArticleeLife2020

Typical and atypical language brain organization based on intrinsic connectivity and multitask functional asymmetries.

Loïc Labache, Bernard Mazoyer, Marc Joliot, Fabrice Crivello, Isabelle Hesling, Nathalie Tzourio-Mazoyer

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
  6. The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
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  10. Effects of Lateralization of Language on Cognition Among Left-Handers.Neurobiology of language (Cambridge, Mass.) · 2025
    Article
  11. Article
  12. Article
  13. Musicianship and Prominence of Interhemispheric Connectivity Determine Two Different Pathways to Atypical Language Dominance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Neuroanatomical correlates of musicianship in left-handers.Behavioral and brain functions : BBF · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Loïc LabacheUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, Bordeaux, France.ORCID 0000-0002-5733-0743
Bernard MazoyerUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, Bordeaux, France.ORCID 0000-0003-0970-2837
Marc JoliotUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, Bordeaux, France.ORCID 0000-0001-7792-308X
Fabrice CrivelloUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, Bordeaux, France.ORCID 0000-0001-6950-984X
Isabelle HeslingUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, Bordeaux, France.ORCID 0000-0002-3719-983X
Nathalie Tzourio-MazoyerUniversité de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, Bordeaux, France.ORCID 0000-0002-6236-4390

Funding

Agence Nationale de la Recherche ANR 16-LCV2-0006-01
6 · The paper itself

Abstract

Based on the joint investigation in 287 healthy volunteers (150 left-Handers (LH)) of language task-induced asymmetries and intrinsic connectivity strength of the sentence-processing supramodal network, we show that individuals with atypical rightward language lateralization (N = 30, 25 LH) do not rely on an organization that simply mirrors that of typical leftward lateralized individuals. Actually, the resting-state organization in the atypicals showed that their sentence processing was underpinned by left and right networks both wired for language processing and highly interacting by strong interhemispheric intrinsic connectivity and larger corpus callosum volume. Such a loose hemispheric specialization for language permits the hosting of language in either the left and/or right hemisphere as assessed by a very high incidence of dissociations across various language task-induced asymmetries in this group.

Indexed as

LanguageAdultBrainBrain MappingCognitionCorpus CallosumFemaleFunctional LateralityHumansMaleNeuropsychological TestsTask Performance and Analysisfmrihandednesshemispheric specializationhumanintrinsic connectivitylanguageneuroscience

Identifiers

PMID33064079
PMCPMC7605859

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.