ArticleEpilepsia2020
Neocortical injury-induced status epilepticus.
Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- From Annotation to Prediction: Hospital-Grade Early Seizure Risk Prediction from Adult EEG.Diagnostics (Basel, Switzerland) · 2026Article
- Respiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus.Epilepsia · 2026Article
- Status epilepticus: Updates on mechanisms and treatments.Epilepsia open · 2025Review
- Thrombin mediates seizures following cortical injury-induced status epilepticus.Epilepsy research · 2025Article
- Article
- Seizure network characterization by functional connectivity mapping and manipulation.Neurophotonics · 2025Article
- Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage.The Journal of pharmacology and experimental therapeutics · 2024Article
- Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy.Neural regeneration research · 2023Article
- Epigallocatechin-3-Gallate Attenuates Leukocyte Infiltration in 67-kDa Laminin Receptor-Dependent and -Independent Pathways in the Rat Frontoparietal Cortex following Status Epilepticus.Antioxidants (Basel, Switzerland) · 2023Article
- Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models.International journal of molecular sciences · 2023Review
- Structural and functional abnormalities in thalamic neurons following neocortical focal status epilepticus.Neurobiology of disease · 2023Article
- Ferulic acid inhibits catamenial epilepsy through modulation of female hormones.Metabolic brain disease · 2022Article
- Epilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder.International journal of molecular sciences · 2022Review
- Current Status of Our Understanding for Brain Integrated Functions and its Energetics.Neurochemical research · 2022Article
- Poly (ADP-ribose) polymerase: An Overview of Mechanistic Approaches and Therapeutic Opportunities in the Management of Stroke.Neurochemical research · 2022Review
- Effect of a Ketogenic Diet on Oxidative Posttranslational Protein Modifications and Brain Homogenate Denaturation in the Kindling Model of Epilepsy in Mice.Neurochemical research · 2022Article
- Antiepileptic Drugs and Their Dual Mechanism of Action on Carbonic Anhydrase.Journal of clinical medicine · 2022Article
- Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization.Annals of neurology · 2022Article
- Neuronal circuits sustaining neocortical-injury-induced status epilepticus.Neurobiology of disease · 2022Article
- A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment.Neurochemical research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo characterize neocortical onset status epilepticus (SE) in the C57BL/6J mouse.
methodsWe induced SE by administering homocysteine 16-18 hours after cobalt (Co) implantation. SE was monitored by video and electroencephalography (EEG). We evaluated brain structure with magnetic resonance imaging (MRI). Neurodegeneration was evaluated 72 hours after SE using Fluoro-Jade C staining.
resultsCobalt triggered seizures in a dose-dependent manner (median effective dose, ED SIGNIFICANCE: We have developed a mouse model of severe, refractory cortical-onset SE, consisting of convulsions merging into a coma, EEG patterns of cortical seizures, and injury, with evidence of widespread neocortical edema and damage. This model replicates many features of acute seizures and SE resulting from traumatic brain injury, subarachnoid, and lobar hemorrhage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.