Evidence map›Paper›PMID 33063667›Full record

ArticleeLife2020

Modular metabolite assembly in

Henry H Le, Chester Jj Wrobel, Sarah M Cohen, Jingfang Yu, Heenam Park, Maximilian J Helf, Brian J Curtis, Joseph C Kruempel, Pedro Reis Rodrigues, Patrick J Hu and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. O-acyltransferase genes involved in the production of volatile sex pheromones inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. The 3D Ultrastructure ofmicroPublication biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Single-tissue proteomics inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Oligonucleotide Catabolism-Derived Gluconucleosides inJournal of the American Chemical Society · 2023
    Article
  20. bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Henry H Le *Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.ORCID 0000-0003-2942-2357
Chester Jj Wrobel *Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Sarah M CohenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Jingfang YuBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.ORCID 0000-0003-1770-5368
Heenam ParkDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Maximilian J HelfBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Brian J CurtisBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Joseph C KruempelDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, United States.
Pedro Reis RodriguesBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.
Patrick J HuDepartments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United States.
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-7699-0173
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-4420-0237
Cornell University · USCalifornia Institute of Technology · USUniversity of Michigan · USVanderbilt University · US

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Enhancing the C. elegans animal resource through genome editingR24OD023041 · OD · UNIVERSITY OF MINNESOTA · PI ROUGVIE, ANN E., STERNBERG, PAUL WARREN · 2017 to 2024
$5.1M
Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
NIGMS NIH HHS R35 GM131877NIGMS NIH HHS T32 GM008500NIH HHS R24 OD023041
6 · The paper itself

Abstract

Signaling molecules derived from attachment of diverse metabolic building blocks to ascarosides play a central role in the life history of

Indexed as

Amino Acid SequenceAnimalsCaenorhabditis elegansCarboxylic Ester HydrolasesGlucosidesLysosomesMetabolic Networks and PathwaysOrganellesSequence AlignmentCarboxylic Ester HydrolasesGlucosidesascarosidesbiochemistrybiosynthesisC. eleganschemical biologymetabolomicsmodular metabolitesnatural productssmall molecule signaling

Identifiers

PMID33063667
PMCPMC7641594
OpenAlexW3093079233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.