Evidence map›Paper›PMID 33063666›Full record

ArticleeLife2020

High-resolution structures of multiple 5-HT

Sandip Basak, Arvind Kumar, Steven Ramsey, Eric Gibbs, Abhijeet Kapoor, Marta Filizola, Sudha Chakrapani

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. RIC-3 Interacts Directly with the 5-HTbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Predicted conformations of 5-HT3 receptor ion channels are modified by subunit D.Computational and structural biotechnology journal · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Structural basis for partial agonism in 5-HTNature structural & molecular biology · 2024
    Article
  10. Review
  11. Article
  12. Superiority of the Triple-Acting 5-HTJournal of medicinal chemistry · 2023
    Article
  13. Article
  14. Article
  15. 5-HTInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sandip BasakDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.ORCID 0000-0003-4018-8020
Arvind KumarDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.ORCID 0000-0002-8421-8669
Steven RamseyDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0001-7441-3228
Eric GibbsDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Abhijeet KapoorDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0002-3606-3463
Marta FilizolaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Sudha ChakrapaniDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.ORCID 0000-0003-0722-2338
Case Western Reserve University · USIcahn School of Medicine at Mount Sinai · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Structure and Function of Pentameric Ligand-Gated Ion ChannelsR35GM134896 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Sudha Chakrapani · 2020 to 2026
$4.7M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
MOLECULAR MECHANISMS OF DESENSITIZATION AND DRUG MODULATION IN LIGAND-GATED ION CHANNELSR01GM108921 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2014 to 2018
$1.9M
STRUCTURE, FUNCTION, AND MODULATION OF SERORTONIN (3A) RECEPTORSR01GM131216 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2019 to 2019
$442k
NEI NIH HHS P30 EY011373NIGMS NIH HHS R01 GM108921NIGMS NIH HHS R01GM108921NIGMS NIH HHS R01 GM131216NIGMS NIH HHS R35 GM134896NIH HHS S10 OD018522NIH HHS S10 OD026880
6 · The paper itself

Abstract

Serotonin receptors (5-HT

Indexed as

AnimalsBinding, CompetitiveBinding SitesCryoelectron MicroscopyFemaleHumansLigandsMiceMolecular Dynamics SimulationOocytesProtein BindingProtein ConformationReceptors, Serotonin, 5-HT3SerotoninSerotonin AntagonistsXenopus laevisLigandsReceptors, Serotonin, 5-HT3SerotoninSerotonin Antagonistsanti-emeticbiochemistrychemical biologyion channelsmolecular biophysicsSetronstructural biology

Identifiers

PMID33063666
PMCPMC7655109
OpenAlexW3093403723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.