Evidence map›Paper›PMID 33063663›Full record

ArticleeLife2020

A natural variant of the essential host gene

Michelle Hays, Janet M Young, Paula F Levan, Harmit S Malik

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Deconstruction ofbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michelle HaysMolecular and Cellular Biology program, University of Washington, Seattle, United States.ORCID 0000-0002-8540-3516
Janet M YoungDivision of Basic Sciences & Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-8220-8427
Paula F LevanDivision of Basic Sciences & Fred Hutchinson Cancer Research Center, Seattle, United States.
Harmit S MalikDivision of Basic Sciences & Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-6005-0016
Fred Hutch Cancer Center · USHoward Hughes Medical Institute · USUniversity of Washington · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Howard Hughes Medical InstituteNational Science Foundation DGE-1256082NHGRI NIH HHS T32 HG000035NIGMS NIH HHS R01 GM074108
6 · The paper itself

Abstract

Antagonistic coevolution with selfish genetic elements (SGEs) can drive evolution of host resistance. Here, we investigated host suppression of 2-micron (2μ) plasmids, multicopy nuclear parasites that have co-evolved with budding yeasts. We developed SCAMPR (Single-Cell Assay for Measuring Plasmid Retention) to measure copy number heterogeneity and 2μ plasmid loss in live cells. We identified three

Indexed as

Genes, FungalGenetic VariationGenomic InstabilityPlasmidsQuantitative Trait LociRepetitive Sequences, Nucleic AcidSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle-Cell AnalysisSUMO-1 ProteinMms21 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSUMO-1 Proteinevolutionary biologygenetic conflictsgeneticsgenomicshigh-copy plasmidsnatural isolatesQTLS. cerevisiaeSmc5/6Smc5/6 complex

Identifiers

PMID33063663
PMCPMC7652418
OpenAlexW3092826200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.