ArticleInvestigational new drugs2021
Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
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Article in Investigational new drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Toward Rational Design of Precision-Fermented Milk Proteins: Integrating Cross-Species Selection, Post-Translational Modification, and AI Optimization.Comprehensive reviews in food science and food safety · 2026Review
- Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways.Oncology research · 2026Article
- Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells.Bioorganic chemistry · 2025Article
- Lactoferrin based copper nanoparticles: a promising anti-cancer strategy against malignant melanoma.Scientific reports · 2025Article
- Advanced Nanoenabled Microalgae Systems: Integrating Oxidative Stress-Induced Metabolic Reprogramming and Enhanced Lipid Biosynthesis for Next-Generation Biofuel Production.ACS applied bio materials · 2025Article
- Anticancer potential of lactoferrin: effects, drug synergy and molecular interactions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches.Frontiers in nutrition · 2025Article
- Effects of pressure on the survival and viability of cancer cells in vitro: An analytical study.PloS one · 2025Article
- Article
- The anticancer activity of bovine lactoferrin is reduced by deglycosylation and it follows a different pathway in cervix and colon cancer cells.Food science & nutrition · 2024Article
- Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections:International journal of pharmaceutics: X · 2023Article
- Therapeutic potential of lactoferrin-coated iron oxide nanospheres for targeted hyperthermia in gastric cancer.Scientific reports · 2023Article
- Anticancer activity of lactoferrin-coated biosynthesized selenium nanoparticles for combating different human cancer cells via mediating apoptotic effects.Scientific reports · 2023Article
- Biomedical Applications of Lactoferrin on the Ocular Surface.Pharmaceutics · 2023Review
- Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines.Investigational new drugs · 2022Article
- Augmenting apoptosis-mediated anticancer activity of lactoperoxidase and lactoferrin by nanocombination with copper and iron hybrid nanometals.Scientific reports · 2022Article
- Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro.Biology · 2022Article
- Lactoferrin as a Human Genome "Guardian"-An Overall Point of View.International journal of molecular sciences · 2022Review
- Plasmalemmal V-ATPase as a Potential Biomarker for Lactoferrin-Based Anticancer Therapy.Biomolecules · 2022Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Sayuri Nakamura-BencomoLaboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario s/n, Campus II, C. P. 31125, Chihuahua, Chih, México.
Denisse A GutierrezThe Cellular Characterization and Biorepository (CCB) Core Facility, Border Biomedical Research Center, Department of Biological Sciences, The University of Texas at El Paso, 500 West University Avenue, El Paso, 79968-0519, TX, USA.ORCID http://orcid.org/0000-0001-5421-2242
Elisa Robles-EscajedaThe Cellular Characterization and Biorepository (CCB) Core Facility, Border Biomedical Research Center, Department of Biological Sciences, The University of Texas at El Paso, 500 West University Avenue, El Paso, 79968-0519, TX, USA.ORCID http://orcid.org/0000-0002-0104-2857
Blanca Iglesias-FigueroaLaboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario s/n, Campus II, C. P. 31125, Chihuahua, Chih, México.ORCID http://orcid.org/0000-0002-8018-5468
Tania S Siqueiros-CendónLaboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario s/n, Campus II, C. P. 31125, Chihuahua, Chih, México.
Edward A Espinoza-SánchezLaboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario s/n, Campus II, C. P. 31125, Chihuahua, Chih, México.ORCID http://orcid.org/0000-0001-5040-0510
Sigifredo Arévalo-GallegosLaboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario s/n, Campus II, C. P. 31125, Chihuahua, Chih, México.ORCID http://orcid.org/0000-0002-3527-1703
Renato J AguileraThe Cellular Characterization and Biorepository (CCB) Core Facility, Border Biomedical Research Center, Department of Biological Sciences, The University of Texas at El Paso, 500 West University Avenue, El Paso, 79968-0519, TX, USA. raguilera@utep.edu.ORCID http://orcid.org/0000-0003-3765-2793
Quintín Rascón-CruzLaboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario s/n, Campus II, C. P. 31125, Chihuahua, Chih, México. qrascon@uach.mx.ORCID http://orcid.org/0000-0001-9879-5988
Armando Varela-RamirezThe Cellular Characterization and Biorepository (CCB) Core Facility, Border Biomedical Research Center, Department of Biological Sciences, The University of Texas at El Paso, 500 West University Avenue, El Paso, 79968-0519, TX, USA. avarela2@utep.edu.ORCID http://orcid.org/0000-0002-2071-4874
Autonomous University of Chihuahua · MXThe University of Texas at El Paso · US
Funding
UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI Gabriel Andrew Frietze · 2019 to 2026
$35.1MTCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4MCharacterization of novel compounds with anti-lymphoma activitySC3GM103713 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2013 to 2016
$453kNIGMS NIH HHS SC3 GM103713NIMHD NIH HHS G12 MD007592NIMHD NIH HHS U54 MD007592
Abstract
Lactoferrin has gained extensive attention due to its ample biological properties. In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)
Indexed as
Actin CytoskeletonApoptosisCell Cycle CheckpointsCell Line, TumorHeLa CellsHumansLactoferrinRecombinant ProteinsSaccharomycetalesLactoferrinRecombinant ProteinsApoptosisCancerCell cycleCytoskeletonDNA fragmentationDrug discoveryHumanized proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.