ArticleJournal of general internal medicine2021
Examining the Potential Impact of Race Multiplier Utilization in Estimated Glomerular Filtration Rate Calculation on African-American Care Outcomes.
Article in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction of chronic kidney disease and its progression by artificial intelligence algorithms.Journal of nephrology · 2022Pooled it
- Global strategies to improve equitable access to heart and lung transplantation- ISHLT Consortium Report.JHLT open · 2026Review
- A Single-Center Assessment of the Race Neutral eGFR Calculation and Access to Kidney Transplantation for Black Patients: A Policy Change Is Not Enough.Journal of racial and ethnic health disparities · 2026Article
- Improving the reliability of polygenic risk score-based prediction for cardiovascular and renal complications across ancestries in type 2 diabetes using Mondrian Cross-Conformal Prediction.PLoS computational biology · 2026Article
- A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- Causal modeling of chronic kidney disease in a participatory framework for informing the inclusion of social drivers in health algorithms.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- A microsimulation-based framework for mitigating societal bias in primary care data.medRxiv : the preprint server for health sciences · 2025Article
- Causal modeling of chronic kidney disease in a participatory framework for informing the inclusion of social drivers in health algorithms.medRxiv : the preprint server for health sciences · 2025Article
- CKD Prevalence and Incidence in Hispanic/Latino Adults Using Race-Free Estimated Glomerular Filtration Rate Equations.Kidney medicine · 2025Article
- Ethnic diversity in precision medicine: a reality or an aspiration?Diabetologia · 2025Review
- Prioritizing precision: guidelines for the better use of population descriptors in human microbiome research.mSystems · 2025Review
- Impact of race-based customization on detection of fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Factors Associated with Pre-Research Recruitment in Autism and Related Developmental Disorders.Journal of autism and developmental disorders · 2025Article
- Simulating mismatch between calibration and target population in AI for mammography the retrospective VAIB study.NPJ digital medicine · 2025Article
- Performance of the 2021 Estimated Glomerular Filtration Rate CKD-EPI Refit and the European Kidney Function Consortium (EKFC) Formulas.Diagnostics (Basel, Switzerland) · 2025Article
- Race as a Risk Marker, Not a Risk Factor: Revising Race-Based Algorithms to Protect Racially Oppressed Patients.Journal of general internal medicine · 2024Article
- Race and ethnicity in physiological research: When socio-political constructs and biology collide.Experimental physiology · 2024Article
- Medical Artificial Intelligence and Human Values.The New England journal of medicine · 2024Review
- Seven Strategies to Integrate Equity within Translational Research in Neurology.Annals of neurology · 2024Review
- Evaluating and Improving the Performance and Racial Fairness of Algorithms for GFR Estimation.medRxiv : the preprint server for health sciences · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvancing health equity entails reducing disparities in care. African-American patients with chronic kidney disease (CKD) have poorer outcomes, including dialysis access placement and transplantation. Estimated glomerular filtration rate (eGFR) equations, which assign higher eGFR values to African-American patients, may be a mechanism for inequitable outcomes. Electronic health record-based registries enable population-based examination of care across racial groups.
objectiveTo examine the impact of the race multiplier for African-Americans in the CKD-EPI eGFR equation on CKD classification and care delivery.
designCross-sectional study
settingTwo large academic medical centers and affiliated community primary care and specialty practices.
participantsA total of 56,845 patients in the Partners HealthCare System CKD registry in June 2019, among whom 2225 (3.9%) were African-American. MEASUREMENTS: Exposures included race, age, sex, comorbidities, and eGFR. Outcomes were transplant referral and dialysis access placement.
resultsOf 2225 African-American patients, 743 (33.4%) would hypothetically be reclassified to a more severe CKD stage if the race multiplier were removed from the CKD-EPI equation. Similarly, 167 of 687 (24.3%) would be reclassified from stage 3B to stage 4. Finally, 64 of 2069 patients (3.1%) would be reassigned from eGFR > 20 ml/min/1.73 m LIMITATIONS: Single healthcare system in the Northeastern United States and relatively small African-American patient cohort may limit generalizability.
conclusionsOur study reveals a meaningful impact of race-adjusted eGFR on the care provided to the African-American CKD patient population.
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