Evidence map›Paper›PMID 33063010›Full record

ArticleNeuro-oncology advances

Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas.

Sydney T Grob, Liana Nobre, Kristen R Campbell, Kurtis D Davies, Scott Ryall, Dara L Aisner, Lindsey Hoffman, Shadi Zahedi, Andrew Morin, Michele Crespo and 10 more

Abstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Analyses of DNA Methylation Profiling in the Diagnosis of Intramedullary Astrocytomas.Journal of neuropathology and experimental neurology · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sydney T GrobDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Liana NobreDepartment of Hematology and Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
Kristen R CampbellDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Kurtis D DaviesDepartment of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
Scott RyallThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Dara L AisnerDepartment of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
Lindsey HoffmanCenter for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.
Shadi ZahediDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Andrew MorinDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Michele CrespoDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Anandani NellanDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.ORCID 0000-0001-8751-2401
Adam L GreenDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Nicholas ForemanDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Rajeev VibhakarDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
Todd C HankinsonThe Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado, USA.
Michael H HandlerThe Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado, USA.
Cynthia HawkinsThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Uri TaboriDepartment of Hematology and Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
B K Kleinschmidt-DeMastersDepartment of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
Jean M Mulcahy LevyDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.ORCID 0000-0002-3022-4246

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Optimization of Autophagy Inhibition as a Clinical Target for Brain TumorsR01NS107313 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MULCAHY LEVY, JEAN MARIE · 2019 to 2023
$1.7M
The Interaction of Autophagy and BRAF Mutations in Brain TumorsK08CA193982 · NCI · UNIVERSITY OF COLORADO DENVER · PI MULCAHY LEVY, JEAN MARIE · 2015 to 2019
$822k
Advancing Treatments for Pediatric Craniopharyngioma (ATPC): Preliminary Assessment of the Cyst Fluid Inflammatory MilieuR03CA212800 · NCI · UNIVERSITY OF COLORADO DENVER · PI HANKINSON, TODD C · 2017 to 2018
$156k
Advancing Treatment for Pediatric Craniopharyngioma (ATPC); in vivo Tocilizumab MeasurementR03CA235200 · NCI · UNIVERSITY OF COLORADO DENVER · PI HANKINSON, TODD C · 2019 to 2020
$156k
NCI NIH HHS K08 CA193982NCI NIH HHS P30 CA046934NCI NIH HHS R03 CA212800NCI NIH HHS R03 CA235200NINDS NIH HHS R01 NS107313
6 · The paper itself

Abstract

backgroundThe mitogen-activated protein kinases/extracelluar signal-regulated kinases pathway is involved in cell growth and proliferation, and mutations in

methodsWe retrospectively analyzed 46 spinal gliomas from patients aged 1-25 years from Children's Hospital Colorado (CHCO) and The Hospital for Sick Children (SickKids). CHCO utilized a 67-gene panel that assessed

resultsOf 31 samples with complete fusion analysis, 13 (42%) harbored

conclusion

Indexed as

BRAFlow-grade gliomaspine

Identifiers

PMID33063010
PMCPMC7542983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.