Evidence map›Paper›PMID 33062943›Full record

ReviewHemaSphere2020

Controversies in the Treatment of Peripheral T-cell Lymphoma.

Emmanuel Bachy, Alessandro Broccoli, Claire Dearden, Laurence de Leval, Philippe Gaulard, Raphael Koch, Franck Morschhauser, Lorenz Trümper, Pier Luigi Zinzani

Abstract readReview
In one paragraph

Review in HemaSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emmanuel BachyHospices Civils de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, Pierre-Bénite, France.
Alessandro BroccoliInstitute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy.
Claire DeardenThe Royal Marsden NHS Foundation Trust and Biomedical Research Centre, Downs Road Sutton, Surrey SM2 5PT, United Kingdom.
Laurence de LevalInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Switzerland.
Philippe GaulardDepartment of Pathology, Henri Mondor Hospital, AP-HP, INSERM U955, University Paris East, Créteil, France.
Raphael KochDepartment of Hematology and Medical Oncology, University Medical Center Gottingen, Germany.
Franck MorschhauserUniversité Lille, CHU Lille, EA 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France.
Lorenz TrümperHaematology/Oncology, UMG Goettingen, Germany.
Pier Luigi ZinzaniInstitute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact in tailoring the treatment. First-line treatment strategies can cure only a minority of patients and relapsed-refractory disease still represents the major cause of failure. Frontline autologous transplantation may have an impact in the consolidation of response; however, its role is still questioned as far as complete responses obtained after induction chemotherapy are concerned. Newer drugs are now being evaluated in clinical trials, but effective salvage strategies for those who experience treatment failures are lacking. Here we review and discuss the most controversial aspects of diagnosis and treatment of peripheral T-cell lymphomas.

Identifiers

PMID33062943
PMCPMC7469987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.