ArticleJournal of dentistry (Shiraz, Iran)2020
Presence of B Cells and Plasma Cells in Oral Lichen Planus.
Article in Journal of dentistry (Shiraz, Iran), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Association between Epstein Barr virus and Oral Lichen Planus clinical phenotypes and p53 expression.Scientific reports · 2025Article
- Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study.BMC oral health · 2025Article
- Plasma Cell Predominance in Lichen Planus Pigmentosus: A Rare Case in a Young Female.Clinical, cosmetic and investigational dermatology · 2025Article
- Humoral immune activation within tertiary lymphoid structures is correlated with poor outcomes in oral lichen planus and lichenoid lesions.Frontiers in immunology · 2025Article
- Comprehensive Insight into Lichen Planus Immunopathogenesis.International journal of molecular sciences · 2023Review
- Single-cell immune profiling reveals immune responses in oral lichen planus.Frontiers in immunology · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
statement of the problemOral lichen planus (OLP) is a chronic inflammatory disease with unknown etiopathogenesis. It was believed that T cells played the major role in developing the lesions. It has been recently suggested that B lymphocyte cells (B cells) and plasma cells may play a role in OLP pathogenesis. PURPOSE: OLP is considered as a T-cell mediated disease. It was believed that the presence of B cells and plasma cells in the sub-epithelial inflammatory infiltrate, rules out the diagnosis of OLP. This study aims to investigate the presence of B cells and plasma cells in the inflammatory infiltrate of OLP. In addition, the association between the presence of B cells and plasma cells with histopathologic features of the lesion was assessed. MATERIALS AND
methodTo assess the presence of B cells and plasma cells, 61 cases with the diagnosis of OLP were collected. The cases with definite clinical and histopathological diagnosis of lichen planus based on WHO criteria were included. For each case, demographic information and histological characteristics were recorded. Specimens underwent immunohistochemical (IHC) staining for CD20 and CD138 and the percentage of the positive cells were counted and scored.
resultsCD20 positive cells existed in all OLP cases with the mean expression of 22.5%± 15.17% and small number of CD138 positive cells were seen in 62.3% of our cases with the mean expression of 4.74%±9.23%. No association was found between histopathological features and CD138 expression, however, CD20 expression level was higher in the cases with parakeratinized surface (
conclusionB cells existed in the inflammatory infiltrate of OLP in all cases. Small number of plasma cells could be occasionally found in OLP. Therefore, presence of B cells and plasma cells in the inflammatory infiltrate cannot rule out the diagnosis of OLP.
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