Evidence map›Paper›PMID 33062690›Full record

ArticleBioMed research international2020

Exosomal circLPAR1 Promoted Osteogenic Differentiation of Homotypic Dental Pulp Stem Cells by Competitively Binding to hsa-miR-31.

Liangkun Xie, Zheng Guan, Mingzhu Zhang, Sha Lyu, Nattawut Thuaksuban, Suttatip Kamolmattayakul, Thongchai Nuntanaranont

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

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  4. Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Liangkun XieDepartment of Oral Implantology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, China.ORCID https://orcid.org/0000-0001-5577-276X
Zheng GuanBiomedical Research Center, The Affiliated Calmette Hospital of Kunming Medical University (the First Hospital of Kunming), Kunming, China.
Mingzhu ZhangDepartment of Periodontology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, China.
Sha LyuBiomedical Research Center, The Affiliated Calmette Hospital of Kunming Medical University (the First Hospital of Kunming), Kunming, China.
Nattawut ThuaksubanDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla, Thailand.
Suttatip KamolmattayakulFaculty of Dentistry, Bangkok Thonburi University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-5202-3429
Thongchai NuntanaranontDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla, Thailand.ORCID https://orcid.org/0000-0002-1748-9063
Kunming Medical University · CNPrince of Songkla University · THBangkokthonburi University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human dental pulp stem cells (DPSCs) hold great promise in bone regeneration. However, the exact mechanism of osteogenic differentiation of DPSCs remains unknown, especially the role of exosomes played in. The DPSCs were cultured and received osteogenic induction; then, exosomes from osteogenic-induced DPSCs (OI-DPSC-Ex) at different time intervals were isolated and sequenced for circular RNA (circRNA) expression profiles. Gradually, increased circular lysophosphatidic acid receptor 1 (circLPAR1) expression was found in the OI-DPSC-Ex coincidentally with the degree of osteogenic differentiation. Meanwhile, results from osteogenic differentiation examinations showed that the OI-DPSC-Ex had osteogenic effect on the recipient homotypic DPSCs. To investigate the mechanism of exosomal circLPAR1 on osteogenic differentiation, we verified that circLPAR1 could competently bind to hsa-miR-31, by eliminating the inhibitory effect of hsa-miR-31 on osteogenesis, therefore promoting osteogenic differentiation of the recipient homotypic DPSCs. Our study showed that exosomal circRNA played an important role in osteogenic differentiation of DPSCs and provided a novel way of utilization of exosomes for the treatment of bone deficiencies.

Indexed as

Dental PulpMicroRNAsReceptors, Lysophosphatidic AcidRNA, CircularCell DifferentiationCells, CulturedExosomesHumansOsteogenesisStem CellsLPAR1 protein, humanMicroRNAsMIRN31 microRNA, humanReceptors, Lysophosphatidic AcidRNA, Circular

Identifiers

PMID33062690
PMCPMC7539105
OpenAlexW3090264175

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.