ReviewCureus2020
Overview of Risk Factors and Prevention of Capsular Contracture Following Implant-Based Breast Reconstruction and Cosmetic Surgery: A Systematic Review.
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of antibiotic prophylaxis for reducing capsular contracture in prosthesis-based breast surgery: a systemic review and meta-analysis.Updates in surgery · 2024Pooled it
- Does Patient History Influence Capsular Contracture? An Exploratory Analysis with Machine Learning.Aesthetic plastic surgery · 2026Article
- Balancing Risk and Reconstruction: A Comprehensive Review of Complications in Delayed Breast Reconstruction.Journal of clinical medicine · 2026Review
- Capsular Contracture in Implant-Based Breast Reconstruction: A Comprehensive Narrative Review of Pathophysiology, Risk Factors, and Contemporary Controversies.Medicina (Kaunas, Lithuania) · 2026Review
- Cosmetic Surgery in the Gulf Cooperation Council: Societal Shifts, Psychological Implications, and Policy Challenges: A Narrative Review.Iranian journal of medical sciences · 2026Review
- Adipose-derived mesenchymal stem cells for the prevention of capsular contracture.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Six Evidence-based Recommendations for Perioperative Incisional Care in Plastic Surgery: A Narrative Review.Plastic and reconstructive surgery. Global open · 2025Article
- Breast Cancer Hormone Therapy Modulates Breast Implant Capsular Contracture.Plastic and reconstructive surgery. Global open · 2025Article
- 3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration.Scientific reports · 2025Article
- Genetic variants in the development of autoimmune complaints and capsular contracture in women with breast implants: A systematic review.JPRAS open · 2025Review
- Breast Reconstruction With Bipedicled DIEP Flap From an Irradiated and Scarred Abdomen.Plastic and reconstructive surgery. Global open · 2025Article
- Analysis of risk factors for capsular contracture after breast augmentation: a retrospective study.Frontiers in surgery · 2025Article
- Unraveling the Immune Web: Advances in SMI Capsular Fibrosis from Molecular Insights to Preclinical Breakthroughs.Biomolecules · 2024Review
- Unveiling the Enigma: Exploring capsular contracture-Unraveling its link with autoimmune disorders and comprehensive examination of predisposing factors.JPRAS open · 2024Review
- Article
- Improvement of Shoulder Motion in Two-Stage Dual-Plane Implant-Based Breast Reconstruction followed by Radiation Therapy through Delayed Prepectoral Conversion.Archives of plastic surgery · 2024Article
- Impact of radiation on immediate breast reconstruction: a retrospective single institution cohort study.Gland surgery · 2023Article
- Silk Bioprotein as a Novel Surgical-Site Wound Dressing: A Prospective, Randomized, Single-Blinded, Superiority Clinical Trial.Aesthetic surgery journal. Open forum · 2023Article
- Keller Funnel Efficacy in "No Touch" Breast Augmentation and Reconstruction: A Systematic Review.Plastic and reconstructive surgery. Global open · 2022Article
- Less fibrosis around softer silicone implants.Nature biomedical engineering · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsular contracture is one of the most common complications of implant-based breast reconstruction or augmentation surgery. Despite advanced molecular biology, the exact mechanism of this complication is not fully understood. PubMed was searched for studies, published from 2015 to 2020, focused on potential risk factors and preventions of capsular contracture (CC) in patients who underwent implant-based breast surgery. A total of 533 articles were identified from PubMed, and 13 articles were selected ultimately for our review after eligibility screening and quality appraisal. Common risk factors of CC include biofilm, surgical site infections (SSI), history of prior CC or fibrosis, history of radiation therapy, and implant characteristics. Interventions that decrease the rate of CC include antibiotic prophylaxis or irrigation, acellular dermal matrix (ADM), leukotriene (LTE) inhibitors, surgical techniques, and others. Multiple risk factors are proposed to be a component of the pathophysiology of CC. However, there is inconsistent evidence supporting these risk factors, and the current data was based on broad heterogeneous studies. While efforts are being undertaken to solve this complication with improved technologies and surgical practices, CC remains to be unsolved. Our objective was to provide a summary of the current data of contributing risk factors as well as preventative and treatment measures for CC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.