Evidence map›Paper›PMID 33062350›Full record

ArticleCase reports in endocrinology2020

ACTH-Independent Cushing's Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential.

Giuseppe S Sica, Leandro Siragusa, Bruno Sensi, Vittoria Bellato, Pierangela Floris, Valentina Rovella, Alessandro Mauriello, Monia Di Prete, Rossana Telesca, Valerio Ciavoni and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giuseppe S SicaDepartment of Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-7407-0584
Leandro SiragusaDepartment of Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
Bruno SensiDepartment of Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
Vittoria BellatoDepartment of Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
Pierangela FlorisDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Valentina RovellaDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Alessandro MaurielloDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Monia Di PreteDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Rossana TelescaDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Valerio CiavoniDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Carmine CardilloDepartment of Internal Medicine, Universitá Cattolica del Sacro Cuore, Rome 00168, Italy.
Nicola Di DanieleDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Manfredi TesauroDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenocortical oncocytomas are rare and mostly nonfunctioning neoplasms. We report the case of a 27-year-old woman diagnosed with an ACTH-independent Cushing's syndrome due to left adrenal oncocytoma. She underwent laparoscopic adrenalectomy. Histopathological examination revealed an oncocytoma of uncertain malignant potential with a low Ki-67 proliferation index, inhibin A positivity, and chromogranin A negativity. Electron micrographs confirmed adrenal oncocytoma cells, characterized by the presence of a large amount of mitochondria. The postoperative course was uneventful, and the patient experienced a progressive regression of Cushing-related symptoms. Periodical follow-ups with MRI and cortisol dosage are required due to the neoplasm's uncertain malignant potential. Considerations on the diagnosis, pathology findings, clinical remarks, and interventions are made.

Identifiers

PMID33062350
PMCPMC7537674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.