Evidence map›Paper›PMID 33062181›Full record

ArticleACS medicinal chemistry letters2020

Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage.

Anjana Sinha, Jerry C Chang, Peng Xu, Katherina Gindinova, Younhee Cho, Weilin Sun, Xianzhong Wu, Yue Ming Li, Paul Greengard, Jeffery W Kelly and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Anjana SinhaLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Jerry C ChangLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Peng XuLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Katherina GindinovaLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Younhee ChoDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Weilin SunLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Xianzhong WuChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Yue Ming LiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Paul GreengardLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Subhash C SinhaLaboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States.
Rockefeller University · USMemorial Sloan Kettering Cancer Center · USScripps Research Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Probing the Biochemical Mechanisms of Amyloid DiseaseR01DK046335 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W · 1998 to 2025
$8.8M
NCI NIH HHS P30 CA008748NIDDK NIH HHS R01 DK046335
6 · The paper itself

Abstract

Tafamidis,

Identifiers

PMID33062181
PMCPMC7549266
OpenAlexW3011725547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.