Evidence map›Paper›PMID 33062176›Full record

ArticleACS medicinal chemistry letters2020

Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A

Dilip K Tosh, Veronica Salmaso, Harsha Rao, Ryan Campbell, Amelia Bitant, Zhan-Guo Gao, John A Auchampach, Kenneth A Jacobson

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Potent and Selective Human 5-HTJournal of medicinal chemistry · 2024
    Article
  4. Lipid Trolling to Optimize AJournal of medicinal chemistry · 2024
    Article
  5. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
  6. Structure activity relationships of 5-HTEuropean journal of medicinal chemistry · 2023
    Article
  7. First Potent Macrocyclic AACS pharmacology & translational science · 2023
    Article
  8. Species dependence of APurinergic signalling · 2023
    Review
  9. Review
  10. Selective AACS medicinal chemistry letters · 2022
    Article
  11. Interaction of AEuropean journal of medicinal chemistry · 2022
    Article
  12. Article
  13. Article
  14. AEuropean journal of medicinal chemistry · 2022
    Article
  15. Review
  16. Review
  17. Adenosine AJournal of neuroinflammation · 2020
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dilip K ToshLaboratory of Bioorganic Chemistry, Mouse Metabolism Core, and Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
Veronica SalmasoLaboratory of Bioorganic Chemistry, Mouse Metabolism Core, and Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
Harsha RaoLaboratory of Bioorganic Chemistry, Mouse Metabolism Core, and Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
Ryan CampbellLaboratory of Bioorganic Chemistry, Mouse Metabolism Core, and Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
Amelia BitantDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Zhan-Guo GaoLaboratory of Bioorganic Chemistry, Mouse Metabolism Core, and Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
John A AuchampachDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, Mouse Metabolism Core, and Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
National Institutes of Health · USMedical College of Wisconsin · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Adenosine Signaling During Post-Infarction Remodeling and Heart FailureR01HL133589 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2017 to 2020
$1.7M
Intramural NIH HHS ZIA DK031117NHLBI NIH HHS R01 HL133589
6 · The paper itself

Abstract

A side-by-side pharmacological comparison of ribose and (N)-methanocarba (bicyclo[3.1.0]hexane) nucleosides as A

Identifiers

PMID33062176
PMCPMC7549272
OpenAlexW3006160572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.