Evidence map›Paper›PMID 33062138›Full record

ArticleOxidative medicine and cellular longevity2020

Anethole Dithiolethione Increases Glutathione in Kidney by Inhibiting

Daniela Giustarini, Federico Galvagni, Isabella Dalle-Donne, Aldo Milzani, Monica Lucattelli, Giovanna De Cunto, Desirée Bartolini, Francesco Galli, Annalisa Santucci, Ranieri Rossi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. How to Increase Cellular Glutathione.Antioxidants (Basel, Switzerland) · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Daniela GiustariniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100 Siena, Italy.ORCID https://orcid.org/0000-0003-4929-5316
Federico GalvagniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100 Siena, Italy.
Isabella Dalle-DonneDepartment of Biosciences, University of Milan, Via Celoria 26, I-20133 Milan, Italy.
Aldo MilzaniDepartment of Biosciences, University of Milan, Via Celoria 26, I-20133 Milan, Italy.
Monica LucattelliDepartment of Molecular and Developmental Medicine, University of Siena, Via A. Moro 2, I-53100 Siena, Italy.
Giovanna De CuntoDepartment of Molecular and Developmental Medicine, University of Siena, Via A. Moro 2, I-53100 Siena, Italy.
Desirée BartoliniDepartment of Pharmaceutical Sciences, University of Perugia, Italy.
Francesco GalliDepartment of Pharmaceutical Sciences, University of Perugia, Italy.
Annalisa SantucciDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100 Siena, Italy.
Ranieri RossiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, I-53100 Siena, Italy.
University of Siena · ITUniversity of Milan · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAnethole dithiolethione (ADT) is a marketed drug to treat xerostomia. Its mechanism of action is still unknown, but several preclinical studies indicate that it is able to increase intracellular glutathione (GSH) and protect against oxidative stress. Here, we investigated the molecular mechanisms behind these effects.

resultsOral treatment of rats confirmed the GSH enhancing properties of ADT; among the different organs examined in this study, only the kidney showed a significant GSH increase that was already observed at low-dose treatments. The increase in GSH correlated with a decrease in

conclusions. The prominent

Indexed as

Anethole TrithioneAnimalsCell LineCysteineDipeptidesDisulfidesgamma-GlutamyltransferaseGlutathioneHumansKidneyKidney Tubules, ProximalMaleMalondialdehydeOxidative StressRatsRats, Sprague-DawleyAnethole TrithioneCysteinecysteinylglycineDipeptidesDisulfidesgamma-GlutamyltransferaseGlutathioneMalondialdehyde

Identifiers

PMID33062138
PMCPMC7539083
OpenAlexW3088982669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.