ArticleFrontiers in zoology2020
Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax.
Article in Frontiers in zoology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Developmental Patterns of Hepatic Peroxisome Proliferator-Activated Receptor (PPAR) Expression in Xenopus laevis and Response to Pharmaceutical Agonists During Metamorphic Climax.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- The gut-liver axis plays a limited role in mediating the liver's heat susceptibility of Chinese giant salamander.BMC genomics · 2025Article
- Every Gain Comes With Loss: Ecological and Physiological Shifts Associated With Polyploidization in a Pygmy Frog.Molecular biology and evolution · 2025Article
- Article
- What frog gill resorption brings: loss of function, cell death, and metabolic reorganization.Frontiers in zoology · 2024Article
- Comparative transcriptomic analysis delineates adaptation strategies of Rana kukunoris toward cold stress on the Qinghai-Tibet Plateau.BMC genomics · 2024Article
- Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation.Frontiers in ecology and evolution · 2024Article
- The effects of two short-chain perfluoroalkyl carboxylic acids (PFCAs) on northern leopard frog (Rana pipiens) tadpole development.Ecotoxicology (London, England) · 2024Article
- Gut microbiota reflect adaptation of cave-dwelling tadpoles to resource scarcity.The ISME journal · 2024Article
- Unveiling vertebrate development dynamics in frog Xenopus laevis using micro-CT imaging.GigaScience · 2024Article
- Integrative proteome and metabolome analyses reveal molecular basis of the tail resorption during the metamorphic climax ofFrontiers in cell and developmental biology · 2024Article
- Early onset of urea synthesis and ammonia detoxification pathways in three terrestrially developing frogs.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Cellular and Molecular Triggers of Retinal Regeneration in Amphibians.Life (Basel, Switzerland) · 2023Review
- Comparative Analysis of Transcriptome Profiles Reveals Distinct and Organ-Dependent Genomic and Nongenomic Actions of Thyroid Hormone inThyroid : official journal of the American Thyroid Association · 2023Article
- Crosstalk between Thyroid Hormone and Corticosteroid Signaling Targets Cell Proliferation inInternational journal of molecular sciences · 2022Article
- Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation.Chinese medicine · 2022Article
- To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Review
- Relationship between serum thyroid hormones and their associated metabolites, and gene expression bioindicators in the back skin ofFrontiers in endocrinology · 2022Article
- Effects of lithium and selenium in the tail muscle of American bullfrog tadpoles (Lithobates catesbeianus) during premetamorphosis.Environmental science and pollution research international · 2022Article
- Effects of Desiccation on Metamorphic Climax inAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetamorphic climax is the crucial stage of amphibian metamorphosis responsible for the morphological and functional changes necessary for transition to a terrestrial habitat. This developmental period is sensitive to environmental changes and pollution. Understanding its metabolic basis and requirements is significant for ecological and toxicological research.
resultsWe used a combined approach of transcriptomics and metabolomics to study the metabolic reorganization during natural and T3-driven metamorphic climax in the liver and tail of
conclusionThe energic strategy and anabolic requirements during metamorphic climax were revealed at the molecular level. Amino acid made an increased contribution to energy metabolism during metamorphic climax. Carbohydrate anabolism was essential for the body construction of the froglets. The tail was critical in anabolism including synthesizing bioactive metabolites. These findings increase our understanding of amphibian metamorphosis and provide background information for ecological, evolutionary, conservation, and developmental studies of amphibians.
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