ArticleEvidence-based complementary and alternative medicine : eCAM2020
Differential Analysis of Serum Principal Components Treated with Compound
Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid-Mass Spectrometry and Molecular Network Binding Antioxidant Activity.Molecules (Basel, Switzerland) · 2024Article
- Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid.International journal of biological sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the differences in the serum principal components in ulcerative colitis- (UC-) induced rats, treated with compound
methodsThe serum samples of rats from each group were obtained after drug administration, and the serum principal components of each group were analyzed by high-resolution mass spectrometry. Agilent Eclipse XDB C18 chromatographic column (100 mm × 2.1 mm, 3.5 m) was used for separation. The mobile phase was water (A) and methanol (B) (0.1% formic acid) gradient elution, 0-3 min (B: 20%-40%), 3-10 min (B: 40%-54%), 10-25 min (B: 54%), 25-35 min (B: 54%-70%), 35-45 min (B: 70%-80%), 45-50 min (B: 80%), 50-60 min (B: 80%-100%), 70-72 min (B: 100%-20%), and 72-77 min (B: 20%); flow rate, 300
resultsIn the negative ion mode, 26 differential compounds were identified in the compound
conclusionBy comparing the differences in the serum principal components from each administration group, we found that the FFKST group exhibited enhanced synthesis of the serum principal components; however, the compound doses of matrine and oxymatrine monomers did not exhibit the same changes in the serum principal components of UC-induced rats. Finally, the traditional Chinese medicine compound is more advantageous than monomers.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.