Evidence map›Paper›PMID 33062012›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2020

Congrong Shujing Granule-Induced GRP78 Expression Reduced Endoplasmic Reticulum Stress and Neuronal Apoptosis in the Midbrain in a Parkinson's Disease Rat Model.

Qian Xu, Shasha Yang, Fangzhen Wu, Yao Lin, Jianan Zhong, Lanfang Tang, Xuefeng Hu, Jing Cai

Abstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qian XuFujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Science, Fujian Normal University, Fuzhou, Fujian 350117, China.ORCID https://orcid.org/0000-0002-7124-3611
Shasha YangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Fangzhen WuDepartment of Rheumatology and Endocrinology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou 350003, China.
Yao LinCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.ORCID https://orcid.org/0000-0001-6832-8334
Jianan ZhongCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Lanfang TangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Xuefeng HuFujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Science, Fujian Normal University, Fuzhou, Fujian 350117, China.
Jing CaiCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.ORCID https://orcid.org/0000-0002-2675-3508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main pathological changes inherent in Parkinson's disease (PD) are degeneration and loss of dopamine neurons in the midbrain and formation of Lewy bodies. Many studies have shown that the pathogenesis of PD is closely related to endoplasmic reticulum (ER) oxidative stress. This study combined various traditional Chinese medicines to prepare Congrong Shujing granules (CSGs). The optimal dose combination of the ingredients was identified by experimental intervention in SH-SY5Y cells

Identifiers

PMID33062012
PMCPMC7547351

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.