Evidence map›Paper›PMID 33061991›Full record

ArticleStem cells international2020

Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing.

Liling Zhao, Zi Guo, Ke Chen, Wenjun Yang, Xinxing Wan, Pingyu Zeng, Honghui He, Yufang Luo, Qian Xiao, Zhaohui Mo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

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  18. [Research advances on stem cell therapy for diabetic foot wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Liling ZhaoDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.ORCID https://orcid.org/0000-0002-5205-2481
Zi GuoDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.ORCID https://orcid.org/0000-0002-2295-0213
Ke ChenDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Wenjun YangDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Xinxing WanDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Pingyu ZengCenter for Experimental Medicine, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Honghui HeDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Yufang LuoDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Qian XiaoDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.
Zhaohui MoDepartment of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 410013.ORCID https://orcid.org/0000-0002-5181-048X
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study is aimed at investigating the effect of combined transplantation of umbilical cord mesenchymal stem cells (UCMSCs) and umbilical cord blood-derived endothelial colony-forming cells (ECFCs) on diabetic foot ulcer healing and at providing a novel therapy for chronic diabetic foot ulcer.

methodsWe reported the treatment of refractory diabetic foot ulcers in twelve patients. Among them, five patients had two or more wounds; thus, one wound in the same patient was treated with cell injection, and other wounds were regarded as self-controls. The remaining seven patients had only one wound; therefore, the difference between the area of wound before and after treatment was estimated. The UCMSCs and ECFCs were injected into the wound along with topically applied hyaluronic acid (HA).

resultsIn this report, we compared the healing rate of multiple separate wounds in the same foot of the same patient: one treated with cell injection combined with topically applied HA-based hydrogel and was later covered by the hydrocolloid dressings, while the self-control wounds were only treated with conventional therapy and covered by the hydrocolloid dressings. The wound underwent cell injection showed accelerated healing in comparison to control wound within the first week after treatment. In other diabetic patients with only one refractory wound, the healing rate after cell transplantation was significantly faster than that before injection. Two large wounds healed without needing skin grafts after combination therapy of cell injection and HA. After four weeks of combination treatment, wound closure was reached in six patients, and the wounds of the other six patients were significantly reduced in size.

conclusionsOur study suggests that the combination of UCMSCs, ECFCs, and HA can safely synergize the accelerated healing of refractory diabetic foot ulcers.

Identifiers

PMID33061991
PMCPMC7545465
OpenAlexW3084305328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.