ArticleFrontiers in psychiatry2020
Enhanced Connectivity of Thalamo-Cortical Networks in First-Episode, Treatment-Naive Somatization Disorder.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks.Communications medicine · 2026Article
- Regional Gene Expression Patterns are Associated with Functional Connectivity Alterations in Major Depressive Disorder with Anxiety Symptoms.Alpha psychiatry · 2025Article
- Phenomena of hypo- and hyperconnectivity in basal ganglia-thalamo-cortical circuits linked to major depression: a 7T fMRI study.Molecular psychiatry · 2025Article
- An important contributing factor in dry eye disease: somatization.International ophthalmology · 2024Observational
- White matter microstructure of children with sensory over-responsivity is associated with affective behavior.Journal of neurodevelopmental disorders · 2024Article
- Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder.Frontiers in neuroscience · 2022Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundDysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with somatization disorder (SD). However, changes in the anatomical specificity of thalamo-cortical functional connectivity (FC) in SD remain unclear.
methodsResting-state fMRI scans were collected in 25 first-episode, drug-naive patients with SD, as well as 28 sex-, age-, and education-matched healthy controls. We parcellated the thalamus with seven predefined regions of interest (ROIs) and used them as seeds to map whole-brain FC. Correlation analysis was conducted in the patients.
resultsWe found an increased pattern of thalamic ROI-cortex connectivity in patients with SD. Patients with SD demonstrated enhanced thalamic connectivity to the bilateral anterior/middle cingulum, motor/sensory cortex, visual cortex, and auditory cortex. A significantly negative correlation was found between the right occipital thalamic ROI to the anterior cingulum and EPQ extraversion scores (
conclusionsThis study demonstrates that anatomical specificity of enhanced thalamo-cortical FCs exists in first-episode, drug-naive patients with SD. These findings further highlight the importance of the thalamic subregions in the pathophysiology of SD.
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